Anastassopoulou J D, Rakintzis N T, Theophanides T
Laboratory of Physical Chemistry, National Technical University, Campus of Zografou, Athens, Greece.
Anticancer Res. 1988 May-Jun;8(3):507-9.
The influence of solubilisation upon the reactivity of the nitroxyl BAPO with the free radicals produced in irradiated vesicle systems was investigated. The decomposition yield G(-BAPO) determined in didodecyldimethyl-ammonium bromide (DDAB) vesicle systems was found to be only 0.04, while in homogeneous aqueous solutions a value of 1.50 was observed. These results, as well as the EPR spectra of irradiated and nonirradiated samples, lead to the conclusion that BAPO is localized in the interior of the bilayer. This behavior is consistent with the hydrophobic character of the nitroxyl molecule due to its benzylidene group.
研究了增溶作用对硝酰基BAPO与辐照囊泡系统中产生的自由基反应活性的影响。在十二烷基二甲基溴化铵（DDAB）囊泡系统中测定的分解产率G（-BAPO）仅为0.04，而在均相水溶液中观察到的值为1.50。这些结果以及辐照和未辐照样品的电子顺磁共振光谱得出结论，BAPO位于双层内部。由于其亚苄基基团，这种行为与硝酰基分子的疏水特性一致。
