Nilakantan Aneesha S, Voss Joel L, Weintraub Sandra, Mesulam M-Marsel, Rogalski Emily J
Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL 60611, USA; Department of Medical Social Sciences, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, IL 60611, USA.
Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL 60611, USA; Department of Medical Social Sciences, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Psychiatry, Northwestern University, Chicago, IL 60611, USA; Department of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA.
Neuropsychologia. 2017 Jun;100:10-17. doi: 10.1016/j.neuropsychologia.2017.04.006. Epub 2017 Apr 6.
Primary progressive aphasia (PPA) is clinically defined by an initial loss of language function and preservation of other cognitive abilities, including episodic memory. While PPA primarily affects the left-lateralized perisylvian language network, some clinical neuropsychological tests suggest concurrent initial memory loss. The goal of this study was to test recognition memory of objects and words in the visual and auditory modality to separate language-processing impairments from retentive memory in PPA. Individuals with non-semantic PPA had longer reaction times and higher false alarms for auditory word stimuli compared to visual object stimuli. Moreover, false alarms for auditory word recognition memory were related to cortical thickness within the left inferior frontal gyrus and left temporal pole, while false alarms for visual object recognition memory was related to cortical thickness within the right-temporal pole. This pattern of results suggests that specific vulnerability in processing verbal stimuli can hinder episodic memory in PPA, and provides evidence for differential contributions of the left and right temporal poles in word and object recognition memory.
原发性进行性失语（PPA）在临床上的定义是最初语言功能丧失而其他认知能力保留，包括情景记忆。虽然PPA主要影响左侧外侧裂周语言网络，但一些临床神经心理学测试表明同时存在初始记忆丧失。本研究的目的是测试在视觉和听觉模式下对物体和单词的识别记忆，以区分PPA中的语言处理障碍和保持性记忆。与视觉物体刺激相比，非语义性PPA个体对听觉单词刺激的反应时间更长且错误警报更高。此外，听觉单词识别记忆的错误警报与左侧额下回和左侧颞极内的皮质厚度有关，而视觉物体识别记忆的错误警报与右侧颞极内的皮质厚度有关。这种结果模式表明，处理言语刺激时的特定易损性会阻碍PPA中的情景记忆，并为左右颞极在单词和物体识别记忆中的不同贡献提供了证据。
