Christensen Adam, Alpert Kathryn, Rogalski Emily, Cobia Derin, Rao Julia, Beg Mirza Faisal, Weintraub Sandra, Mesulam M-Marsel, Wang Lei
Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
Alzheimers Dement (Amst). 2015 Mar 1;1(1):14-23. doi: 10.1016/j.dadm.2014.11.013.
Alzheimer neuropathology (AD) is found in almost half of patients with non-semantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic AD.
In 37 PPA patients and 32 healthy controls, we generated hippocampal subfield surface maps from structural MRIs and administered a face memory test. We analyzed group and hemisphere differences for surface shape measures and their relationship with test scores and ApoE genotype.
The hippocampus in PPA showed inward deformity (CA1 and subiculum subfields) and outward deformity (CA2-4+DG subfield) and smaller left than right volumes. Memory performance was related to hippocampal shape abnormalities in PPA patients, but not controls, even in the absence of memory impairments.
Hippocampal deformity in PPA is related to memory test scores. This may reflect a combination of intrinsic degenerative phenomena with transsynaptic or Wallerian effects of neocortical neuronal loss.
在近半数非语义性原发性进行性失语（PPA）患者中发现了阿尔茨海默神经病理学特征（AD）。本研究检查了PPA患者的海马异常情况，以确定其与遗忘型AD中所描述的异常情况的相似性。
对37例PPA患者和32名健康对照者，我们从结构磁共振成像生成海马亚区表面图谱，并进行面部记忆测试。我们分析了组间和半球间在表面形状测量方面的差异及其与测试分数和载脂蛋白E基因型的关系。
PPA患者的海马表现为向内畸形（CA1和下托亚区）和向外畸形（CA2 - 4 +齿状回亚区），且左侧体积小于右侧。即使在没有记忆障碍的情况下，PPA患者的记忆表现也与海马形状异常有关，而对照者则不然。
PPA患者的海马畸形与记忆测试分数有关。这可能反映了内在退行性现象与新皮质神经元丢失的跨突触或华勒氏效应的结合。
