Mayer M
Palacký University, Department of Biochemistry, Olomouc, Czechoslovakia.
Biomed Biochim Acta. 1988;47(1):83-7.
The adherence changes induced by the ionophore A23187 and by the leukotrienes, respectively, were investigated in 10 healthy persons. The calcium ionophore A23187 in concentrations of 200 nM, 1 microM and 5 microM induced inhibition of mononuclear leukocyte adherence in a concentration-dependent manner, the maximal adherence inhibition being proved with 5 microM ionophore. The leukotrienes did not significantly alter leukocyte adherence in the test system used. The results of this study suggest that the calcium ionophore A23187-induced leukocyte adherence inhibition may serve as a pharmacological model of the leukocyte adherence inhibition phenomenon, thus providing a useful tool for the investigation of the processes associated with some cellular membrane functions.
分别在10名健康受试者中研究了离子载体A23187和白三烯诱导的黏附变化。浓度为200 nM、1 μM和5 μM的钙离子载体A23187以浓度依赖的方式诱导单核白细胞黏附受到抑制，5 μM离子载体显示出最大的黏附抑制作用。在所使用的测试系统中，白三烯并未显著改变白细胞的黏附。本研究结果表明，钙离子载体A23187诱导的白细胞黏附抑制可能作为白细胞黏附抑制现象的药理学模型，从而为研究与某些细胞膜功能相关的过程提供了一个有用的工具。
