Hu Xiaochen, Uhle Franziska, Fliessbach Klaus, Wagner Michael, Han Ying, Weber Bernd, Jessen Frank
Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany; Department of Psychiatry and Psychotherapy, University Hospital of Bonn, Bonn, Germany.
Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Alzheimers Dement (Amst). 2017 Mar 14;6:222-231. doi: 10.1016/j.dadm.2017.02.005. eCollection 2017.
Subjective cognitive decline (SCD) refers to an at-risk state of Alzheimer's disease and subtle cognitive deficits that have been observed in this condition. Currently, it is unknown whether complex cognitive processes relevant to everyday life, such as future-oriented choice behavior, are also altered in SCD.
Twenty SCD participants and 24 control (CO) participants took part in a functional magnetic resonance imaging task on intertemporal decisions, with and without simultaneous episodic future imagination.
SCD participants showed reduced future-oriented choices. Future imagination increased future-oriented choices and was associated with increased brain activation in medial frontal polar cortex, right insular cortex, and anterior cingulate cortex in CO only, not SCD. In addition, more future-oriented choices were associated with hippocampal activation during choice processing in CO only.
Subtle neuronal network disruptions in SCD may underlie their myopic future decisions and lack of modulation of choice behavior by episodic future imagination.
主观认知衰退（SCD）指的是阿尔茨海默病的一种风险状态以及在此状态下观察到的细微认知缺陷。目前，尚不清楚与日常生活相关的复杂认知过程，如面向未来的选择行为，在SCD中是否也会发生改变。
20名SCD参与者和24名对照（CO）参与者参加了一项关于跨期决策的功能磁共振成像任务，该任务有或没有同时进行情景性未来想象。
SCD参与者表现出较少的面向未来的选择。未来想象增加了面向未来的选择，并且仅在CO组中与内侧额极皮质、右侧岛叶皮质和前扣带回皮质的脑激活增加相关，而在SCD组中则不然。此外，仅在CO组中，更多面向未来的选择与选择过程中海马体的激活相关。
SCD中细微的神经网络破坏可能是其近视的未来决策以及情景性未来想象对选择行为缺乏调节作用的基础。
