Milroy R, McKillop J, Smith L, Banham S
Department of Respiratory Medicine, Royal Infirmary, Glasgow, UK.
Eur J Nucl Med. 1988;14(2):57-9.
We have undertaken gallium imaging studies in 49 patients with histologically proven small cell lung cancer. Tracer uptake in the primary tumour was seen in 98% of cases. Twenty five patients underwent repeat scanning after induction chemotherapy and a correlation was demonstrated between conventional parameters of response and gallium scan changes (P less than 0.01). There was no correlation between initial gallium activity and subsequent chemoresponse (which was evaluated in 32 patients) or survival (measured in 42 patients). Ten patients who had shown a complete response to induction treatment were followed up with gallium scans repeated at three monthly intervals. Such longitudinal studies were particularly helpful in excluding tumour activity when the appearance of the chest radiographs were difficult to interpret.
我们对49例经组织学证实的小细胞肺癌患者进行了镓显像研究。98%的病例在原发肿瘤中可见示踪剂摄取。25例患者在诱导化疗后接受了重复扫描，结果显示反应的传统参数与镓扫描变化之间存在相关性（P<0.01）。初始镓活性与随后的化疗反应（在32例患者中进行评估）或生存率（在42例患者中进行测量）之间无相关性。对诱导治疗显示完全缓解的10例患者每隔三个月重复进行镓扫描随访。当胸部X光片的表现难以解释时，此类纵向研究对于排除肿瘤活性特别有帮助。
