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非那雄胺的不良反应:最新情况

[Finasteride adverse effects: An update].

作者信息

Carreño-Orellana Néstor, Moll-Manzur Catherina, Carrasco-Zuber Juan Eduardo, Álvarez-Véliz Sergio, Berroeta-Mauriziano Daniela, Porras-Kusmanic Ninoska

机构信息

Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

Rev Med Chil. 2016 Dec;144(12):1584-1590. doi: 10.4067/S0034-98872016001200010.

DOI:10.4067/S0034-98872016001200010
PMID:28393993
Abstract

Finasteride is a 5-α reductase inhibitor that is widely used in the management of benign prostate hyperplasia and male pattern hair loss. It is well known that these agents improve the quality of life in men suffering from these conditions. However, they are associated with some transient and even permanent adverse effects. The aim of this article is to clarify the controversies about the safety of finasteride by analyzing the evidence available in the literature.

摘要

非那雄胺是一种5-α还原酶抑制剂,广泛用于治疗良性前列腺增生和男性型脱发。众所周知,这些药物可改善患有这些病症的男性的生活质量。然而,它们会带来一些短暂甚至永久性的副作用。本文的目的是通过分析文献中的现有证据来澄清关于非那雄胺安全性的争议。

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1
[Finasteride adverse effects: An update].非那雄胺的不良反应:最新情况
Rev Med Chil. 2016 Dec;144(12):1584-1590. doi: 10.4067/S0034-98872016001200010.
2
Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?5α还原酶抑制剂疗法对雄激素性脱发男性的不良影响:是否需要担忧?
Actas Dermosifiliogr. 2016 Nov;107(9):709-711. doi: 10.1016/j.ad.2016.06.006. Epub 2016 Jul 18.
3
Therapeutic hotline. Treatment of androgenic alopecia with finasteride may result in a high grade prostate cancer in patients: fact or fiction?治疗热线。用非那雄胺治疗雄激素性脱发可能会导致患者的前列腺癌等级升高:这是事实还是虚构?
Dermatol Ther. 2010 Sep-Oct;23(5):544-6. doi: 10.1111/j.1529-8019.2010.01358.x.
4
Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis.5α-还原酶抑制剂治疗良性前列腺增生患者的性功能障碍:一项全面综述和荟萃分析。
Andrology. 2017 Jul;5(4):671-678. doi: 10.1111/andr.12353. Epub 2017 Apr 28.
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Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.5α-还原酶抑制剂治疗的不良反应:一部分患者持续出现性欲减退、勃起功能障碍和抑郁。
J Sex Med. 2011 Mar;8(3):872-84. doi: 10.1111/j.1743-6109.2010.02157.x. Epub 2010 Dec 22.
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The Impact of 5α-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health.5α-还原酶抑制剂用于男性型脱发对男性健康的影响。
Curr Urol Rep. 2018 Jun 16;19(8):65. doi: 10.1007/s11934-018-0814-z.
7
On call. I have read several news reports that claim finasteride, which I take for my prostate problem, can cause permanent impotence. Should I be concerned?正在值班。我读了几篇新闻报道,称我因前列腺问题服用的非那雄胺可能会导致永久性阳痿。我应该担心吗?
Harv Mens Health Watch. 2013 Jan;17(6):2.
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Persistent sexual side effects of finasteride for male pattern hair loss.非那雄胺治疗男性型脱发的持续性性副作用。
J Sex Med. 2011 Jun;8(6):1747-53. doi: 10.1111/j.1743-6109.2011.02255.x. Epub 2011 Mar 18.
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Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?5α-还原酶抑制剂的不良反应:我们知道什么、不知道什么以及需要知道什么?
Rev Endocr Metab Disord. 2015 Sep;16(3):177-98. doi: 10.1007/s11154-015-9319-y.
10
Finasteride: middle-age cure-all for alopecia and benign prostatic hyperplasia?
Mayo Clin Proc. 2006 Feb;81(2):267; author reply 267-8. doi: 10.4065/81.2.267.

引用本文的文献

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The combination of water extracts of Radix and Flos improves benign prostatic hyperplasia by suppressing testosterone-induced proliferation of prostate cells and .根与花的水提取物组合通过抑制睾酮诱导的前列腺细胞增殖来改善良性前列腺增生。
Nutr Res Pract. 2025 Jun;19(3):345-360. doi: 10.4162/nrp.2025.19.3.345. Epub 2024 Dec 9.
2
Adipose-derived stromal vascular fraction (SVF) for the treatment of androgenic alopecia (AGA): a systematic review.脂肪来源的基质血管成分(SVF)治疗雄激素性脱发(AGA):系统评价。
Acta Biomed. 2023 Oct 17;94(5):e2023236. doi: 10.23750/abm.v94i5.15069.
3
C.A. meyer alleviates benign prostatic hyperplasia while preventing finasteride-induced side effects.
C.A. 迈耶在预防非那雄胺引起的副作用的同时减轻良性前列腺增生。
Front Pharmacol. 2023 Jan 12;14:1039622. doi: 10.3389/fphar.2023.1039622. eCollection 2023.
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Physicochemical Characterization of Chitosan-Decorated Finasteride Solid Lipid Nanoparticles for Skin Drug Delivery.壳聚糖修饰的非那雄胺固体脂质纳米粒的理化性质及其经皮给药研究。
Biomed Res Int. 2022 Aug 6;2022:7792180. doi: 10.1155/2022/7792180. eCollection 2022.
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Relationship between hair shedding and systemic inflammation in COVID-19 pneumonia.新型冠状病毒肺炎中毛发脱落与全身炎症的关系。
Ann Med. 2022 Dec;54(1):869-874. doi: 10.1080/07853890.2022.2054026.
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Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice.甲酰肽受体2缺乏通过调节小鼠毛囊干细胞和真皮乳头细胞的激活来延缓毛发再生。
Dev Reprod. 2021 Dec;25(4):279-291. doi: 10.12717/DR.2021.25.4.279. Epub 2021 Dec 31.
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Protective Role of 4-(4-Hydroxy-3-methoxyphenyl)-2-Butanone on Prostatic Cells Hyperplasia of Rats and Human, 5α-reductase Inhibition Pathway.4-(4-羟基-3-甲氧基苯基)-2-丁酮对大鼠和人前列腺细胞增生的保护作用及5α-还原酶抑制途径
J Microsc Ultrastruct. 2021 May 24;9(4):164-169. doi: 10.4103/JMAU.JMAU_37_20. eCollection 2021 Oct-Dec.
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Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach.用于治疗雄激素性脱发的非那雄胺纳米传递体凝胶配方:体外研究方法
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