Hanly J G
Division of Rheumatology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Canada.
Lupus. 2017 Apr;26(5):497-503. doi: 10.1177/0961203317690244.
Neuropsychiatric events in systemic lupus erythematosus patients may present a diagnostic and therapeutic challenge. Common and heterogeneous, their characterization and attribution to systemic lupus erythematosus and non-systemic lupus erythematosus is important and derived from clinical assessment, selection and interpretation of investigations. A standardized approach to assigning attribution has been used in recent studies. The current therapies are largely empiric, based upon known disease mechanisms and treatment of other serious organ disease in systemic lupus erythematosus. Further insight on the immunopathogenetic mechanisms and clinical outcome of neuropsychiatric systemic lupus erythematosus is required to inform the design and execution of therapeutic clinical trials.
系统性红斑狼疮患者的神经精神事件可能带来诊断和治疗方面的挑战。这些事件常见且具有异质性，明确其与系统性红斑狼疮及非系统性红斑狼疮的关联并进行特征描述非常重要，这需要通过临床评估、检查的选择和解读来实现。近期研究采用了一种标准化的归因方法。目前的治疗很大程度上是经验性的，基于系统性红斑狼疮已知的疾病机制以及其他严重器官疾病的治疗方法。需要进一步深入了解神经精神性系统性红斑狼疮的免疫发病机制和临床结局，以便为治疗性临床试验的设计和实施提供依据。
