Grover Sumit, Garg Bhavna, Sood Neena, Arora Kamaldeep
a Department of Pathology , Dayanand Medical College and Hospital , Tagore Nagar, Ludhiana , India.
b Department of Neonatology , Dayanand Medical College and Hospital , Tagore Nagar, Ludhiana , India.
Fetal Pediatr Pathol. 2017 Jun;36(3):220-231. doi: 10.1080/15513815.2017.1303859. Epub 2017 Apr 10.
Congenital malformations (CMF) are major causes of fetal demise which can be detected antenatally by Ultrasonography (USG).
We studied 100 perinatal autopsies for CMF. Sensitivity of USG was determined and accuracy of USG with that of autopsy was compared.
At Autopsy 134 individual CMF were seen in 40 cases. The sensitivity of USG in detecting major CMF was 54.47%. A complete agreement between autopsy and USG findings was seen in 13/40 (32.5%) and partial agreement in 17/40 (42.5%) fetuses while autopsy completely changed antenatal diagnosis in 10/40 (25%) fetuses. Major findings were added in all 17 fetuses with partial agreement. In 2 cases, CMF suspected on USG were not detected on autopsy due to fetal maceration.
Autopsy significantly adds to the prenatal USG diagnosis and may help in predicting the probability of recurrence, and thus counseling the affected couple to prevent any such future event.
先天性畸形（CMF）是导致胎儿死亡的主要原因，可通过超声检查（USG）在产前检测到。
我们对100例围产期先天性畸形尸体解剖进行了研究。确定了超声检查的敏感性，并将超声检查与尸体解剖的准确性进行了比较。
在尸体解剖中，40例中发现了134例个体先天性畸形。超声检查检测主要先天性畸形的敏感性为54.47%。在13/40（32.5%）的胎儿中，尸体解剖和超声检查结果完全一致，在17/40（42.5%）的胎儿中部分一致，而在10/40（25%）的胎儿中，尸体解剖完全改变了产前诊断。在所有17例部分一致的胎儿中都增加了主要发现。在2例中，由于胎儿浸软，超声检查怀疑的先天性畸形在尸体解剖中未被检测到。
尸体解剖显著增加了产前超声诊断的内容，可能有助于预测复发的可能性，从而为受影响的夫妇提供咨询，以防止未来发生任何此类事件。
