Foulds G, Brennan D R, Wajszczuk C, Catanzaro A, Garg D C, Knopf W, Rinaldi M, Weidler D J
Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
J Clin Pharmacol. 1988 Apr;28(4):363-6. doi: 10.1002/j.1552-4604.1988.tb03159.x.
One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid.
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