Becskei Csilla, Cherni Judith A, Vatta Adriano F, King Vickie L, Lin Dan, Rugg Douglas
Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, Zaventem B-1930, Belgium.
Zoetis, Veterinary Medicine Research and Development, 333 Portage Street, Kalamazoo, MI 49007, USA.
Vet Parasitol. 2017 Apr;238 Suppl 1:S18-S21. doi: 10.1016/j.vetpar.2017.03.010.
The efficacy of a new spot-on formulation of selamectin plus sarolaner against induced flea infestations in cats was confirmed in three placebo-controlled, blinded studies. Purpose-bred adult cats (n=8/group) were blocked by pre-treatment flea counts and randomly allocated to treatment with either a placebo or with the spot-on formulation at the minimum dose of 6.0mg selamectin and 1.0mg sarolaner per kg bodyweight. Treatments were applied topically once on Day 0. All cats were infested with approximately 100 unfed, adult Ctenocephalides felis prior to treatment and at weekly intervals for 5 weeks. In Studies 1 and 2 comb counts were conducted to determine the numbers of viable fleas 24h after treatment and subsequent weekly infestations. In Study 3, flea counts were conducted at 6, 12, 24 and 48h after treatment and 3, 6, 12 and 24h after subsequent weekly infestations to evaluate the speed of kill against fleas. Cats in the placebo-treated groups maintained flea infestations throughout all studies. In Study 1, no live fleas were found on any of the treated cats, resulting in 100% efficacy for 5 weeks after a single treatment (P≤0.0001). In Study 2, selamectin/sarolaner reduced flea counts by 92.4% immediately after treatment and by 97.7%-100% after re-infestations for five weeks (P≤0.0001). In the speed of kill study, selamectin/sarolaner started killing fleas within 12h after treatment administration and within 6h following re-infestation for at least 28days. Efficacy was 98.1% by 24h after treatment and 100% within 24h after re-infestations for 5 weeks. A single topical administration of a new spot-on formulation of selamectin plus sarolaner at the minimum dose rapidly and consistently kills fleas on cats for at least 5 weeks.
在三项安慰剂对照、双盲研究中证实了一种新的含有塞拉菌素加沙罗拉纳的滴剂配方对猫身上诱导性跳蚤感染的疗效。按目的培育的成年猫（每组8只）根据治疗前跳蚤计数进行分组，并随机分配接受安慰剂治疗或接受滴剂配方治疗，最低剂量为每千克体重6.0毫克塞拉菌素和1.0毫克沙罗拉纳。在第0天进行一次局部给药。所有猫在治疗前以及之后5周每周接受一次约100只未进食的成年猫栉首蚤感染。在研究1和2中，进行梳检以确定治疗后24小时以及随后每周感染后存活跳蚤的数量。在研究3中，在治疗后6、12、24和48小时以及随后每周感染后3、6、12和24小时进行跳蚤计数，以评估对跳蚤的杀灭速度。安慰剂治疗组的猫在所有研究中均维持跳蚤感染状态。在研究1中，任何一只接受治疗的猫身上均未发现活跳蚤，单次治疗后5周的疗效达100%（P≤0.0001）。在研究2中，塞拉菌素/沙罗拉纳在治疗后立即使跳蚤数量减少92.4%，在再次感染5周后减少97.7%-100%（P≤0.0001）。在杀灭速度研究中，塞拉菌素/沙罗拉纳在给药后12小时内开始杀灭跳蚤，在再次感染后6小时内开始杀灭跳蚤，至少持续28天。治疗后24小时的疗效为98.1%，再次感染5周后24小时内的疗效为100%。以最低剂量单次局部施用新的含有塞拉菌素加沙罗拉纳的滴剂配方可快速且持续地杀死猫身上的跳蚤至少5周。
