El Ochi Mohamed Reda, Oukabli Mohamed, Bouaiti Elarbi, Chahdi Hafsa, Boudhas Adil, Allaoui Mohamed, Ameur Ahmed, Abbar Mohamed, Al Bouzidi Abderrahmane
Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.
Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.
BMC Clin Pathol. 2017 Apr 4;17:3. doi: 10.1186/s12907-017-0046-z. eCollection 2017.
Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. Despite many reports in the literature, the prognostic significance of this overexpression remains unclear. The aim of this study was to assess the expression of HER2 in urothelial bladder carcinomas and its association with clinical and pathological parameters.
103 cases of UBC were diagnosed in our department between January 2014 and December 2015. The tumor specimens obtained by transurethral resection or cystectomy were evaluated by immunohistochemistry using HER2 antibody.
HER2 protein overexpression was present in 11.7% of cases and associated with tumor grade ( = 0.003) and pathological stage ( = 0.015). In multivariate analysis, HER2 overexpression was associated only with tumor grade ( = 0.04).
HER2 protein overexpression is noted in patients with high grade cancer. This expression may select patients for anti HER2 targeted therapy. Future larger and prospective studies will verify the frequency of HER2 alteration and the role of HER2 in the aggressive behavior.
尿路上皮膀胱癌（UBC）是全球男性中最常见的癌症之一。在多种尿路上皮癌中均检测到人类表皮生长因子受体2（HER2）表达。尽管文献中有许多报道，但这种过表达的预后意义仍不清楚。本研究的目的是评估HER2在尿路上皮膀胱癌中的表达及其与临床和病理参数的关联。
2014年1月至2015年12月期间，我科诊断了103例UBC。通过经尿道切除术或膀胱切除术获得的肿瘤标本，使用HER2抗体通过免疫组织化学进行评估。
11.7%的病例存在HER2蛋白过表达，且与肿瘤分级（=0.003）和病理分期（=0.015）相关。在多变量分析中，HER2过表达仅与肿瘤分级相关（=0.04）。
在高级别癌症患者中发现HER2蛋白过表达。这种表达可能为抗HER2靶向治疗选择患者。未来更大规模的前瞻性研究将验证HER2改变的频率以及HER2在侵袭性行为中的作用。
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