HER2表达在膀胱癌中的临床意义及预后价值：一项荟萃分析和生物信息学分析
The Clinical Significance and Prognostic Value of HER2 Expression in Bladder Cancer: A Meta-Analysis and a Bioinformatic Analysis.
作者信息
Gan Kai, Gao Yue, Liu Kuangzheng, Xu Bin, Qin Weijun
机构信息
Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Surgical Research Center, Institute of Urology, Medical School of Southeast University, Nanjing, China.
出版信息
Front Oncol. 2021 Sep 1;11:653491. doi: 10.3389/fonc.2021.653491. eCollection 2021.
OBJECTIVE
Human Epidermal Growth Factor Receptor 2 (HER2) is highly expressed in multiple malignancies and associated with patients' prognosis, but its role in bladder cancer (BCa) remains elusive. We conducted this meta-analysis to explore the clinical significance and prognostic value of HER2 in BCa.
METHODS
PubMed was searched for studies published between January 1, 2000 and January 1, 2020. The odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were used to investigate the relationship between HER2 and BCa pathological features. TCGA was mined for the information regarding as well.
RESULTS
Our study included 14 articles enrolling 1398 people. Expression of HER2 is higher in bladder cancer than in normal tissues. HER2 over-expression is associated with CIS, multifocal tumor, large tumor size, high tumor stage and grade, lymph node metastasis, progression, recurrence and papillary tumor. We could not find a significant association between HER2 expression and survival time in BCa patients.
CONCLUSIONS
Our meta and bioinformatic analysis indicated that HER2 expression was related to pathological malignancy and poor prognosis in BCa.
目的
人表皮生长因子受体2（HER2）在多种恶性肿瘤中高表达并与患者预后相关，但其在膀胱癌（BCa）中的作用仍不明确。我们进行了这项荟萃分析以探讨HER2在BCa中的临床意义和预后价值。
方法
检索PubMed中2000年1月1日至2020年1月1日发表的研究。采用比值比（OR）和风险比（HR）及95%置信区间（95%CI）来研究HER2与BCa病理特征之间的关系。同时也从癌症基因组图谱（TCGA）中挖掘相关信息。
结果
我们的研究纳入了14篇文章，共1398人。HER2在膀胱癌中的表达高于正常组织。HER2过表达与原位癌、多灶性肿瘤、肿瘤体积大、肿瘤分期和分级高、淋巴结转移、进展、复发及乳头状肿瘤相关。我们未发现HER2表达与BCa患者生存时间之间存在显著关联。
结论
我们的荟萃分析和生物信息学分析表明，HER2表达与BCa的病理恶性程度及不良预后相关。
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