Piegat Agnieszka, Fray Mirosława El
West Pomeranian University of Technology, Szczecin, Poland.
Polim Med. 2016 Jan-Jun;46(1):79-87. doi: 10.17219/pim/65099.
Heart assisting devices have become a standard element in clinical practice and provide support for the traditional methods of treating heart disease. Regardless of the construction of VAD (ventricular assist devices), there are crucial requirements that have to be met by the construction materials: high purity, desired physical, chemical and mechanical properties, easy fabrication and high stability and susceptibility to sterilization. They must not cause thrombosis, destroy cellular elements, alter plasma protein, destroy enzymes, deplete electrolytes, cause immune response and cancer, and must not produce toxic and allergic reactions, when they are applied in direct contact with biological tissues and fluids. This paper provides an overview of the polymeric materials as construction materials for cardiovascular support systems, focusing on the group of thermoplastic elastomers, mainly polyurethane and polyester based ones. It also highlights the advantages and disadvantages of currently used materials and the progress in the design of new materials with potential application in the biomedical field.
心脏辅助装置已成为临床实践中的标准组成部分，并为传统心脏病治疗方法提供支持。无论心室辅助装置（VAD）的构造如何，其构造材料都必须满足关键要求：高纯度、所需的物理、化学和机械性能、易于制造、高稳定性以及易于灭菌。当它们直接与生物组织和流体接触时，不得引起血栓形成、破坏细胞成分、改变血浆蛋白、破坏酶、消耗电解质、引起免疫反应和癌症，并且不得产生毒性和过敏反应。本文概述了作为心血管支持系统构造材料的聚合物材料，重点介绍了热塑性弹性体，主要是基于聚氨酯和聚酯的热塑性弹性体。它还强调了当前使用材料的优缺点以及在生物医学领域具有潜在应用的新材料设计进展。
