Nørredam Marie, Porskrog Anders, Ocias Lukas Frans, Knudsen Jenny Dahl
Ugeskr Laeger. 2017 Feb 20;179(8).
Talaromyces marneffei is a dimorphic fungus, which may cause life-threatening opportunistic infections in immuno-compromised individuals. A 25-year-old woman from Thailand was admitted with fever, shortness of breath, cough, and weight loss. The symptoms had persisted for three weeks. The patient had a stopover in Copenhagen on her way to Thailand from Greenland. A thoracic X-ray showed bilateral interstitial changes. Examinations showed positive HIV-test with a CD4-count of 21/microlitre. Moreover, fungaemia with T. marneffei was detected by cultivation. Highly active antiretroviral therapy and IV amphotericin B treatment was initiated followed by perorally administrated itraconazole.
马尔尼菲篮状菌是一种双相真菌，可在免疫功能低下的个体中引起危及生命的机会性感染。一名来自泰国的25岁女性因发热、呼吸急促、咳嗽和体重减轻入院。这些症状持续了三周。该患者在从格陵兰前往泰国的途中在哥本哈根停留过。胸部X光显示双侧间质改变。检查显示HIV检测呈阳性，CD4细胞计数为21/微升。此外，通过培养检测到马尔尼菲篮状菌血症。开始进行高效抗逆转录病毒治疗和静脉注射两性霉素B治疗，随后口服伊曲康唑。
