Poulsen Christina Gjerlev, Bestle Morten, Boesby Lene
Ugeskr Laeger. 2017 Feb 13;179(7).
In the course of an uncomplicated sigmoidostomy a 63-year-old male who had severe comorbidity developed a critical bleeding due to dabigatran intoxication induced by acute kidney injury. Massive blood transfusions, tranexamic acid, Octaplex and haemodialysis were not effective. Administration of idarucizumab induced immediate clinical and paraclinical improvement. Dabigatran should be carefully administrated in patients who have any degree of renal insufficiency. Idarucizumab may be effective in severe bleeding caused by dabigatran.
在一次简单的乙状结肠造口术中，一名患有严重合并症的63岁男性因急性肾损伤导致达比加群中毒而发生严重出血。大量输血、氨甲环酸、凝血因子复合物和血液透析均无效。给予依达赛珠单抗后临床和辅助检查结果立即改善。对于有任何程度肾功能不全的患者，应谨慎使用达比加群。依达赛珠单抗可能对达比加群引起的严重出血有效。
