铜（I）催化的环丙醇开环氰化反应

Copper(i)-catalyzed ring-opening cyanation of cyclopropanols.

作者信息

Feng Yi-Si, Shu Yong-Jin, Cao Ping, Xu Tao, Xu Hua-Jian

机构信息

School of Chemistry and Chemical Engineering, School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China.

出版信息

Org Biomol Chem. 2017 May 3;15(17):3590-3593. doi: 10.1039/c7ob00627f.

DOI:10.1039/c7ob00627f

PMID:28397930

Abstract

A copper(i)-catalyzed ring-opening cyanation of cyclopropanols was developed. The reaction provides an alternative method to achieve β-cyano ketones efficiently. This reaction exhibits good functional group compatibility under mild conditions and can be scaled up to the gram scale. Preliminary mechanistic studies suggest that the reaction might go through a free radical process.

摘要

开发了一种铜（I）催化的环丙醇开环氰化反应。该反应为高效合成β-氰基酮提供了一种替代方法。该反应在温和条件下表现出良好的官能团兼容性，并且可以扩大到克级规模。初步机理研究表明，该反应可能通过自由基过程进行。