• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

四种具有抑制海百合Alloeocomatella polycladia丙型肝炎病毒NS3解旋酶作用的芳香硫酸酯。

Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia.

作者信息

Hermawan Idam, Furuta Atsushi, Higashi Masahiro, Fujita Yoshihisa, Akimitsu Nobuyoshi, Yamashita Atsuya, Moriishi Kohji, Tsuneda Satoshi, Tani Hidenori, Nakakoshi Masamichi, Tsubuki Masayoshi, Sekiguchi Yuji, Noda Naohiro, Tanaka Junichi

机构信息

Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.

出版信息

Mar Drugs. 2017 Apr 11;15(4):117. doi: 10.3390/md15040117.

DOI:10.3390/md15040117
PMID:28398249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5408263/
Abstract

Bioassay-guided separation of a lipophilic extract of the crinoid , inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates -. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates - showed moderate inhibition against NS3 helicase with IC values of 71, 95, 7, and 5 μM, respectively.

摘要

对抑制丙型肝炎病毒NS3解旋酶活性的海百合类亲脂性提取物进行生物测定指导的分离，得到了两组分子：硫酸胆固醇和四种新的芳香族硫酸盐。除理论研究外，还通过光谱分析阐明了芳香族化合物的结构。芳香族硫酸盐对NS3解旋酶表现出中等程度的抑制作用，IC值分别为71、95、7和5 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/7f54abfc96b9/marinedrugs-15-00117-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/5688b4998975/marinedrugs-15-00117-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/27513dcf87b4/marinedrugs-15-00117-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/21d75c349681/marinedrugs-15-00117-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/39df26521b2f/marinedrugs-15-00117-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/7f54abfc96b9/marinedrugs-15-00117-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/5688b4998975/marinedrugs-15-00117-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/27513dcf87b4/marinedrugs-15-00117-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/21d75c349681/marinedrugs-15-00117-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/39df26521b2f/marinedrugs-15-00117-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f495/5408263/7f54abfc96b9/marinedrugs-15-00117-g005.jpg

相似文献

1
Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia.四种具有抑制海百合Alloeocomatella polycladia丙型肝炎病毒NS3解旋酶作用的芳香硫酸酯。
Mar Drugs. 2017 Apr 11;15(4):117. doi: 10.3390/md15040117.
2
Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.海洋羽星 Alloeocomatella polycladia 的乙酸乙酯提取物抑制丙型肝炎病毒复制和病毒解旋酶。
Mar Drugs. 2012 Apr;10(4):744-761. doi: 10.3390/md10040744. Epub 2012 Mar 28.
3
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.胆固醇硫酸酯作为丙型肝炎病毒 NS3 解旋酶的潜在抑制剂。
J Enzyme Inhib Med Chem. 2014 Apr;29(2):223-9. doi: 10.3109/14756366.2013.766607. Epub 2013 Feb 25.
4
Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.抑制丙型肝炎病毒NS3蛋白酶和螺旋酶活性的高效双功能适体的设计与分析
Nucleic Acids Symp Ser (Oxf). 2004(48):195-6. doi: 10.1093/nass/48.1.195.
5
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.鉴定羟基蒽醌为丙型肝炎病毒NS3解旋酶的新型抑制剂
Int J Mol Sci. 2015 Aug 7;16(8):18439-53. doi: 10.3390/ijms160818439.
6
Psammaplin A inhibits hepatitis C virus NS3 helicase.沙巴林 A 抑制丙型肝炎病毒 NS3 解旋酶。
J Nat Med. 2013 Oct;67(4):765-72. doi: 10.1007/s11418-013-0742-7. Epub 2013 Jan 29.
7
Fluoroquinolones inhibit HCV by targeting its helicase.氟喹诺酮类药物通过作用于丙型肝炎病毒（HCV）的解旋酶来抑制该病毒。
Antivir Ther. 2012;17(3):467-76. doi: 10.3851/IMP1937. Epub 2011 Oct 25.
8
Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication.新型吖啶酮衍生物的合成，作为 NS3 解旋酶抑制剂，能有效地、有针对性地抑制亚基因组 HCV 复制。
J Med Chem. 2010 Apr 22;53(8):3117-26. doi: 10.1021/jm901741p.
9
PBDE: structure-activity studies for the inhibition of hepatitis C virus NS3 helicase.多溴二苯醚：针对丙型肝炎病毒NS3解旋酶抑制作用的构效关系研究
Molecules. 2014 Apr 2;19(4):4006-20. doi: 10.3390/molecules19044006.
10
Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle.蛋白酶抑制剂在丙型肝炎病毒生命周期中阻断NS3/4A蛋白酶-解旋酶的多种功能。
J Virol. 2015 May;89(10):5362-70. doi: 10.1128/JVI.03188-14. Epub 2015 Mar 4.

引用本文的文献

1
Molecular basis of pigment structural diversity in echinoderms.棘皮动物色素结构多样性的分子基础。
iScience. 2024 Aug 30;27(9):110834. doi: 10.1016/j.isci.2024.110834. eCollection 2024 Sep 20.
2
HBCVTr: an end-to-end transformer with a deep neural network hybrid model for anti-HBV and HCV activity predictor from SMILES.HBCVTr：一种用于从SMILES预测抗HBV和HCV活性的具有深度神经网络混合模型的端到端变压器。
Sci Rep. 2024 Apr 22;14(1):9262. doi: 10.1038/s41598-024-59933-4.
3
Marine Pharmacology in 2016-2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

本文引用的文献

1
An Ocean of Discovery: Biodiversity Beyond the Census of Marine Life.发现之海：海洋生物普查之外的生物多样性
Planta Med. 2016 Jun;82(9-10):790-9. doi: 10.1055/s-0042-103934. Epub 2016 Apr 19.
2
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.鉴定羟基蒽醌为丙型肝炎病毒NS3解旋酶的新型抑制剂
Int J Mol Sci. 2015 Aug 7;16(8):18439-53. doi: 10.3390/ijms160818439.
3
A fluorescence-based screening assay for identification of hepatitis C virus NS3 helicase inhibitors and characterization of their inhibitory mechanism.
2016 - 2017年海洋药理学：具有抗菌、抗糖尿病、抗真菌、抗炎、抗原虫、抗结核和抗病毒活性的海洋化合物；影响免疫和神经系统以及其他杂项作用机制
Mar Drugs. 2021 Jan 21;19(2):49. doi: 10.3390/md19020049.
一种基于荧光的筛选试验，用于鉴定丙型肝炎病毒NS3解旋酶抑制剂并表征其抑制机制。
Methods Mol Biol. 2015;1259:211-28. doi: 10.1007/978-1-4939-2214-7_14.
4
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.胆固醇硫酸酯作为丙型肝炎病毒 NS3 解旋酶的潜在抑制剂。
J Enzyme Inhib Med Chem. 2014 Apr;29(2):223-9. doi: 10.3109/14756366.2013.766607. Epub 2013 Feb 25.
5
Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.海洋羽星 Alloeocomatella polycladia 的乙酸乙酯提取物抑制丙型肝炎病毒复制和病毒解旋酶。
Mar Drugs. 2012 Apr;10(4):744-761. doi: 10.3390/md10040744. Epub 2012 Mar 28.
6
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.海洋天然产物药物发现与化学生物学的过往经验与未来展望
Chem Biol. 2012 Jan 27;19(1):85-98. doi: 10.1016/j.chembiol.2011.12.014.
7
Marine natural products: a new wave of drugs?海洋天然产物：新药浪潮？
Future Med Chem. 2011 Sep;3(12):1475-89. doi: 10.4155/fmc.11.118.
8
Quantum mechanical continuum solvation models.量子力学连续介质溶剂化模型。
Chem Rev. 2005 Aug;105(8):2999-3093. doi: 10.1021/cr9904009.
9
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs.合成的和载体衍生的小干扰RNA对细胞内丙型肝炎病毒复制的抑制作用。
EMBO Rep. 2003 Jun;4(6):602-8. doi: 10.1038/sj.embor.embor840.