四种具有抑制海百合Alloeocomatella polycladia丙型肝炎病毒NS3解旋酶作用的芳香硫酸酯。

Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia.

作者信息

Hermawan Idam, Furuta Atsushi, Higashi Masahiro, Fujita Yoshihisa, Akimitsu Nobuyoshi, Yamashita Atsuya, Moriishi Kohji, Tsuneda Satoshi, Tani Hidenori, Nakakoshi Masamichi, Tsubuki Masayoshi, Sekiguchi Yuji, Noda Naohiro, Tanaka Junichi

机构信息

Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.

出版信息

Mar Drugs. 2017 Apr 11;15(4):117. doi: 10.3390/md15040117.

Bioassay-guided separation of a lipophilic extract of the crinoid , inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates -. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates - showed moderate inhibition against NS3 helicase with IC values of 71, 95, 7, and 5 μM, respectively.