Ganatra Sarju, Majithia Arjun, Yeh Yun-Ting Eric, Levy Michael S
Lahey Hospital & Medical Center, Burlington, Massachusetts.
Catheter Cardiovasc Interv. 2017 Sep 1;90(3):476-479. doi: 10.1002/ccd.27045. Epub 2017 Apr 11.
Ultrasound-assisted catheter-directed thrombolysis therapy has emerged more recently as a management strategy for patients with intermediate risk pulmonary embolism and has shown promising results in clinical trials by early reversal of right ventricle dilation, reduced pulmonary hypertension, and decreased anatomic thrombus burden. This therapeutic strategy requires a small fraction of the systemic fibrinolytic dose and is therefore associated with a reduced bleeding risk. Although intracranial hemorrhage has not been reported in clinical trials, it is a possible complication. Here we report the first case of intracranial hemorrhage related to the use of EkoSonic™ Endovascular System directed thrombolysis in a patient with large bilateral pulmonary embolism without any identifiable bleeding risks. © 2017 Wiley Periodicals, Inc.
超声辅助导管直接溶栓治疗最近已成为中度风险肺栓塞患者的一种管理策略，并且在临床试验中已显示出有前景的结果，可早期逆转右心室扩张、降低肺动脉高压并减轻解剖学血栓负荷。这种治疗策略所需的全身纤溶剂量仅为一小部分，因此出血风险降低。尽管临床试验中尚未报告颅内出血，但它是一种可能的并发症。在此，我们报告首例与使用EkoSonic™血管内系统进行直接溶栓相关的颅内出血病例，该患者患有双侧大面积肺栓塞，且无任何可识别的出血风险。© 2017威利期刊公司
