地佐辛降低乳腺癌患者胰岛素水平。
Diazoxide for Lowering Insulin Levels in Breast Cancer Patients.
机构信息
Onkologische Praxis, Fuerth, Germany
Department of Radiotherapy and Radiation Oncology, Leopoldina Hospital Schweinfurt, Schweinfurt, Germany.
出版信息
Oncologist. 2017 Apr;22(4):491. doi: 10.1634/theoncologist.2016-0402.
Abstract
Diazoxide is a nondiuretic benzothiadiazine that produces hyperglycemia by lowering insulin levels through activation of ATP‐sensitive K1‐channels and stimulating insulin degradation in the lysosomal system. Its effect on cancer growth is discussed.
摘要
二氮嗪是一种非利尿苯并噻二嗪类药物，通过激活 ATP 敏感性 K + 通道降低胰岛素水平，并刺激溶酶体系统中胰岛素降解，从而导致高血糖。本文讨论了其对肿瘤生长的影响。
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本文引用的文献
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Pretreatment Insulin Levels as a Prognostic Factor for Breast Cancer Progression.治疗前胰岛素水平作为乳腺癌进展的预后因素
Oncologist. 2016 Sep;21(9):1041-9. doi: 10.1634/theoncologist.2015-0462. Epub 2016 Jul 7.
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Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis.生酮饮食对小鼠的抗肿瘤作用：一项荟萃分析。
PLoS One. 2016 May 9;11(5):e0155050. doi: 10.1371/journal.pone.0155050. eCollection 2016.
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Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer.胰岛素/胰岛素样生长因子-1系统的饮食和药物调节：充分利用全套抗癌方法。
Oncogenesis. 2016 Feb 15;5(2):e193. doi: 10.1038/oncsis.2016.2.
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Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats.外源性补充酮体对斯普拉格-道利大鼠血液中酮体、葡萄糖、甘油三酯和脂蛋白水平的影响。
Nutr Metab (Lond). 2016 Feb 4;13:9. doi: 10.1186/s12986-016-0069-y. eCollection 2016.
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Effects of diazoxide-induced reversible diabetes on chemically induced autochthonous mammary carcinomas in Sprague-Dawley rats.二氮嗪诱导的可逆性糖尿病对斯普拉格-道利大鼠化学诱导的自发性乳腺癌的影响。
Int J Cancer. 1985 Mar 15;35(3):395-401. doi: 10.1002/ijc.2910350316.
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