Gualde N, Cook J M, Guibert F
Groupe de Recherche en Immunologie et Biochimie, Faculté de Médecine et de Pharmacie, Limoges, France.
APMIS. 1988 Jun;96(6):531-6.
Since there is a good deal of evidence that vicia villosa lectin (VVA) binds to contrasuppressor cells, mouse splenocytes and thymocytes were sorted by binding to VVA-coated Petri dishes. It was observed that vicia villosa adherent cells (VVA(+)) did not proliferate when mitogens were added to cultures, but they did enhance the thymidine uptake of PHA or ConA stimulated vicia villosa non-adherent (VVA(-)) splenocytes. PGE2 treatment of VVA(+) splenocytes or VVA(+) immature thymocytes did not very much affect the VVA(+) cell behavior. On the other hand, LTB4 increased the enhancing capability of VVA(+) splenocytes. Therefore, investigations dealing with the effects of LTB4 on lymphocyte subsets which may include VVA(+) cells should take into consideration the possible presence of contrasuppressor cells.
由于有大量证据表明野豌豆凝集素（VVA）与抗抑制细胞结合，因此通过与包被有VVA的培养皿结合对小鼠脾细胞和胸腺细胞进行分选。观察到，当向培养物中添加促细胞分裂剂时，野豌豆黏附细胞（VVA(+)）不会增殖，但它们确实会增强PHA或ConA刺激的野豌豆非黏附（VVA(-)）脾细胞的胸腺嘧啶核苷摄取。用PGE2处理VVA(+)脾细胞或VVA(+)未成熟胸腺细胞对VVA(+)细胞行为影响不大。另一方面，LTB4增加了VVA(+)脾细胞的增强能力。因此，研究LTB4对可能包括VVA(+)细胞的淋巴细胞亚群的影响时，应考虑抗抑制细胞可能的存在。
