肾上腺素能受体介导的人离体心室心肌动作电位和收缩力变化
Adrenoceptor-mediated changes of action potential and force of contraction in human isolated ventricular heart muscle.
作者信息
Jakob H, Nawrath H, Rupp J
机构信息
Pharmakologisches Institut, Universität Mainz, Federal Republic of Germany.
出版信息
Br J Pharmacol. 1988 Jun;94(2):584-90. doi: 10.1111/j.1476-5381.1988.tb11564.x.
Abstract
- The effects of alpha-adrenoceptor stimulation on the action potential and force of contraction were investigated in human isolated ventricular heart muscle and compared with those of beta-adrenoceptor stimulation. 2. The maximal stimulation by isoprenaline of beta-adrenoceptors produced large changes in the force of contraction, which were accompanied by moderate increases in the height of the action potential. The maximal inotropic effect produced by stimulation of alpha-adrenoceptors with phenylephrine, in the presence of propranolol (1 mumol 1(-1)) was much smaller (about 10% of that seen in response to beta-adrenoceptor stimulation), and no significant changes of the action potential configuration were observed. 3. The effects of noradrenaline and adrenaline on the force of contraction were not affected by prazosin. 4. It is concluded that the adrenoceptor-mediated changes of the force of contraction (in the presence of either noradrenaline or adrenaline) in the human ventricle are due virtually exclusively to the stimulation of beta-adrenoceptors.
摘要
- 研究了α-肾上腺素能受体刺激对人离体心室肌动作电位和收缩力的影响，并与β-肾上腺素能受体刺激的影响进行了比较。2. 异丙肾上腺素对β-肾上腺素能受体的最大刺激使收缩力发生了很大变化，同时动作电位高度适度增加。在普萘洛尔（1 μmol/L）存在的情况下，用去氧肾上腺素刺激α-肾上腺素能受体产生的最大正性肌力作用要小得多（约为β-肾上腺素能受体刺激反应的10%），且未观察到动作电位形态的显著变化。3. 去甲肾上腺素和肾上腺素对收缩力的影响不受哌唑嗪的影响。4. 得出结论，人心室中（在去甲肾上腺素或肾上腺素存在的情况下）肾上腺素能受体介导的收缩力变化几乎完全是由于β-肾上腺素能受体的刺激。
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