中枢α和β肾上腺素能受体参与大鼠延髓头端腹外侧区电刺激的升压反应。
Involvement of central alpha- and beta-adrenoceptors in the pressor response to electrical stimulation of the rostral ventrolateral medulla in rats.
作者信息
Ward-Routledge C, Marshall P, Marsden C A
机构信息
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham.
出版信息
Br J Pharmacol. 1988 Jun;94(2):609-19. doi: 10.1111/j.1476-5381.1988.tb11567.x.
Abstract
- Electrical stimulation of the C1 area of the rostral ventrolateral medulla in rats elicits an increase in mean arterial pressure (MAP). 2. This increase in MAP is attenuated by intra-hypothalamic and intracisternal administration of the non-selective beta-adrenoceptor antagonist (+/-)-propranolol and the beta 2-selective antagonist ICI 118551. 3. The selective beta 1-antagonist atenolol and (+)-propranolol, which is inactive on beta-adrenoceptors, did not alter the increase in MAP produced by stimulation of the C1 area. 4. The alpha 2-adrenoceptor antagonist idazoxan enhanced the effects of C1 stimulation on MAP when administered either into the posterior hypothalamus or intracisternally. 5. The results indicate that beta 2- and alpha 2-receptors both have a role in the mediation of the rise in MAP during stimulation of the C1 area and that the receptors involved are located both within the hypothalamus and the spinal cord.
摘要
- 对大鼠延髓头端腹外侧C1区进行电刺激可使平均动脉压（MAP）升高。2. 下丘脑内和脑池内给予非选择性β-肾上腺素能受体拮抗剂（±）-普萘洛尔和β2选择性拮抗剂ICI 118551可减弱MAP的这种升高。3. 选择性β1拮抗剂阿替洛尔和对β-肾上腺素能受体无活性的（+）-普萘洛尔不会改变刺激C1区所产生的MAP升高。4. α2肾上腺素能受体拮抗剂咪唑克生经下丘脑后部给药或脑池内给药时，可增强C1刺激对MAP的作用。5. 结果表明，β2和α2受体在C1区刺激期间MAP升高的介导过程中均起作用，且所涉及的受体位于下丘脑和脊髓内。
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