18F-氟脱氧葡萄糖正电子发射断层扫描在与全身型幼年特发性关节炎相关的巨噬细胞活化综合征中的应用
FDG-PET in macrophage activation syndrome associated with systemic juvenile idiopathic arthritis.
作者信息
Shimizu Masaki, Ikawa Yasuhiro, Mizuta Mao, Takakura Maiko, Inoue Natsumi, Nishimura Ryosei, Yachie Akihiro
机构信息
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
出版信息
Pediatr Int. 2017 Apr;59(4):509-511. doi: 10.1111/ped.13238.
We herein describe a case of systemic juvenile idiopathic arthritis (s-JIA)-associated macrophage activation syndrome (MAS) in which the fluorodeoxyglucose positron emission tomography ( FDG-PET) findings were characteristic. The pattern of greater FDG accumulation into the spleen compared with the liver was more remarkable in this patient compared with s-JIA. This pattern, however, was also observed in cases of acute leukemia. In the present patient, serum interleukin (IL)-18 was extremely elevated (255 000 pg/mL), whereas in leukemia patients it is mildly elevated (360-1480 pg/mL). FDG-PET might be a useful indicator of s-JIA and MAS in patients with fever of unknown origin. The pattern of FDG accumulation, however, can also be observed in acute leukemia. The combination of FDG-PET and serum IL-18 might be useful for the diagnosis of s-JIA and MAS.
我们在此描述一例系统性幼年特发性关节炎（s-JIA）相关巨噬细胞活化综合征（MAS），其中氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）结果具有特征性。与肝脏相比，该患者脾脏中FDG积聚更多的模式比s-JIA患者更为显著。然而，这种模式在急性白血病病例中也有观察到。在本例患者中，血清白细胞介素（IL）-18极度升高（255 000 pg/mL），而白血病患者中则轻度升高（360-1480 pg/mL）。FDG-PET可能是不明原因发热患者s-JIA和MAS的有用指标。然而，FDG积聚模式在急性白血病中也可观察到。FDG-PET和血清IL-18的联合应用可能有助于s-JIA和MAS的诊断。
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