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[疑似肺癌的快速诊断路径:以患者为中心的方法]

[Fast diagnostic track for suspected lung cancer: A patient centered approach].

作者信息

Hardardottir Hronn, Valdimarsdottir Unnur A, Gudbjartsson Tomas, Sigvaldason Andres, Lund Sigrun Helga, Aspelund Thor, Hansdottir Sif, Jonsson Steinn

出版信息

Laeknabladid. 2017 Apr;103(4):171-177. doi: 10.17992/lbl.2017.04.130.

Abstract

INTRODUCTION

The aim of this study is to describe the characteristics of patients who underwent a fast diagnostic track (FDT) due to suspected lung cancer at Landspitali University Hospital, Iceland.

MATERIAL AND METHODS

Hospital records were reviewed on background characteristics, diagnosis, staging, waiting times and survival of all 550 patients (mean age 68.1 years, 57% female) that participated in the FDT from February 1, 2008 to January 31, 2015. Adjusting for clinical characteristics in a multivariate analysis, overall survival was compared for patients diagnosed with lung cancer within or outside the FDT in Iceland in 2014 (n=167, mean age 69.3 years, 61.7% female).

RESULTS

Of the 550 FDT patients, 426 were diagnosed with lung cancer (77.5%); 346 of the non-small cell type (NSCLC) (81.2%). The proportion of patients receiving lung cancer diagnosis through the FDT increased from 23.3% in 2008 to 47.9% in 2014 (p<0.001). The waiting time from referral to diagnosis was 10 days median and 19 days from diagnosis to initiation of treatment. More patients with advanced disease were diagnosed outside the FDT (70.1% vs. 37.5%, p<0.05). When ad-- justed for age, sex, histology, stage at diagnosis and therapy, patients diagnosed with lung cancer outside the FDT had higher risk of all-cause mortality (HR 1.60; 95% CI: 0.95 - 2.71) although the difference was not statistically significant.

CONCLUSION

An increasing proportion of lung cancer diagnosis in Iceland is made through a fast diagnostic track with potential benefits for patients. The waiting time from referral to diagnosis and treatment is in line with international guidelines. Key words: lung cancer, non-small cell lung cancer, diagnostic track, waiting times, survival. Correspondence: Hronn Hardardottir, hronnh@landspitali.is.

摘要

引言

本研究旨在描述冰岛兰斯皮塔利大学医院因疑似肺癌而接受快速诊断路径(FDT)的患者特征。

材料与方法

回顾了2008年2月1日至2015年1月31日参与FDT的所有550例患者(平均年龄68.1岁,57%为女性)的医院记录,内容包括背景特征、诊断、分期、等待时间和生存情况。在多变量分析中对临床特征进行调整后,比较了2014年在冰岛FDT内或FDT外被诊断为肺癌的患者的总生存率(n = 167,平均年龄69.3岁,61.7%为女性)。

结果

在550例FDT患者中,426例被诊断为肺癌(77.5%);其中346例为非小细胞型(NSCLC)(81.2%)。通过FDT接受肺癌诊断的患者比例从2008年的23.3%增至2014年的47.9%(p<0.001)。从转诊到诊断的等待时间中位数为10天,从诊断到开始治疗为19天。更多晚期疾病患者在FDT外被诊断(70.1%对37.5%,p<0.05)。在对年龄、性别、组织学、诊断时的分期和治疗进行调整后,在FDT外被诊断为肺癌的患者全因死亡风险较高(HR 1.60;95% CI:0.95 - 2.71),尽管差异无统计学意义。

结论

冰岛通过快速诊断路径进行肺癌诊断的比例不断增加,这对患者可能有益。从转诊到诊断和治疗的等待时间符合国际指南。关键词:肺癌;非小细胞肺癌;诊断路径;等待时间;生存。通信作者:赫伦·哈达尔多蒂尔,hronnh@landspitali.is

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