AK021443 在非小细胞肺癌中的表达水平及临床意义。
Expression Level and Clinical Significance of AK021443 in Non-Small-Cell Lung Carcinoma.
机构信息
Department of Oncology, Suzhou Hospital Affiliated to Anhui Medical University (Suzhou Municipal Hospital), Suzhou, China.
Department of Respiratory Medicine, Yancheng Third People's Hospital, The Affiliated Yancheng Hospital of Southeast University, Yancheng, China.
出版信息
J Healthc Eng. 2022 Mar 14;2022:7957121. doi: 10.1155/2022/7957121. eCollection 2022.
To explore the prognostic potential of AK021443 in non-small-cell lung carcinoma (NSCLC), AK021443 levels in NSCLC specimens were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The correlation between the AK021443 level and pathological factors in NSCLC patients was analyzed. Kaplan-Meier curves were plotted for assessing the prognostic value of AK021443 in NSCLC patients. Potential factors influencing NSCLC prognosis were analyzed by multivariable Cox regression test. AK021443 was upregulated in NSCLC specimens than normal ones. Its level was correlated to histological type, tumor differentiation, TNM staging, and lymphatic metastasis in NSCLC patients. AK021443 was the independent risk factor for the overall survival of NSCLC. AK021443 is highly expressed in NSCLC specimens, which is correlated to histological type, tumor differentiation, TNM staging, and lymphatic metastasis in NSCLC patients. It is the independent prognostic factor for NSCLC.
为了探究 AK021443 在非小细胞肺癌（NSCLC）中的预后潜力，我们通过实时定量聚合酶链反应（qRT-PCR）检测了 NSCLC 标本中的 AK021443 水平。分析了 AK021443 水平与 NSCLC 患者病理因素之间的相关性。Kaplan-Meier 曲线用于评估 AK021443 在 NSCLC 患者中的预后价值。通过多变量 Cox 回归检验分析了影响 NSCLC 预后的潜在因素。AK021443 在 NSCLC 标本中呈高表达，与 NSCLC 患者的组织学类型、肿瘤分化、TNM 分期和淋巴转移有关。AK021443 是 NSCLC 总生存期的独立危险因素。AK021443 在 NSCLC 标本中呈高表达，与 NSCLC 患者的组织学类型、肿瘤分化、TNM 分期和淋巴转移有关。它是非小细胞肺癌的独立预后因素。
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