铜催化的A-偶联反应合成N-炔丙基亚砜亚胺
Synthesis of N-Propargylsulfoximines by Copper-Catalyzed A -Couplings.
作者信息
Cheng Hanchao, Wen Jian, Bolm Carsten
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
出版信息
Chemistry. 2017 Sep 7;23(50):12100-12103. doi: 10.1002/chem.201700953. Epub 2017 May 2.
PMID:28401993
Abstract
An efficient synthesis of N-propargylsulfoximines was developed through a copper-catalyzed coupling of aldehydes, alkynes, and NH-sulfoximines. The reaction requires no co-catalyst or ligand and shows a wide substrate scope with moderate to good yields.
摘要
通过铜催化的醛、炔烃和N-亚磺酰亚胺的偶联反应，开发了一种高效合成N-炔丙基亚磺酰亚胺的方法。该反应无需共催化剂或配体，底物范围广泛，产率适中至良好。
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