Serdengeçti S, Büyükünal E, Molinas N, Demirelli F H, Berkarda N, Eyüboğlu H, Derman U, Berkarda B
Oncology Section, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
Chemioterapia. 1988 Apr;7(2):117-21.
The effects of different chemotherapy protocols on survival were evaluated in 197 small cell lung cancer patients followed-up between 1974 and 1987 in our unit. Of these, 170 patients had Stage IV disease and 24 had Stage III disease. Thoracic radiotherapy was given to 73 patients of whom 63 had Stage IV disease. Cytotoxic chemotherapy was given in four main protocols consisting of cyclophosphamide (CYC): CYC + vincristine (VCR); CYC + VCR + adriamycin (ADM) and CYC + VCR + ADM + lomustine (CCNU). The latter protocol was associated with the highest survival rates and differed significantly (p less than 0.05) from the others. In patients with extensive disease, both radiotherapy to the primary site and adjuvant immunomodulation in conjunction with the above chemotherapy regimens lacked any beneficial effect on survival.
1974年至1987年间，我们单位对197例小细胞肺癌患者进行随访，评估了不同化疗方案对生存率的影响。其中，170例患者为IV期疾病，24例为III期疾病。73例患者接受了胸部放疗，其中63例为IV期疾病。细胞毒性化疗采用四种主要方案，包括环磷酰胺（CYC）：CYC + 长春新碱（VCR）；CYC + VCR + 阿霉素（ADM）以及CYC + VCR + ADM + 洛莫司汀（CCNU）。后一种方案的生存率最高，与其他方案有显著差异（p小于0.05）。在广泛期疾病患者中，对原发部位进行放疗以及联合上述化疗方案进行辅助免疫调节对生存率均无任何有益影响。
