Terres W, Hamm C W, Kupper W, Bleifeld W
Abteilung für Kardiologie, Universitätskrankenhaus Eppendorf, Hamburg.
Dtsch Med Wochenschr. 1988 Jul 29;113(30):1182-6. doi: 10.1055/s-2008-1067790.
In a prospective study, platelet aggregation in platelet-rich plasma after ADP stimulation (0.5, 1.0 and 10 mumol/l) and collagen (1 and 5 micrograms/ml) was measured in 36 patients with coronary heart disease, 18 with angina at rest during the eight hours preceding the time of blood sampling, and 18 patients with stable, exercise-dependent angina, matched for age and sex. In addition, c-AMP was determined, before and (as a measure of platelet adenylate cyclase activity) after stimulation of this enzyme by prostaglandin E1 (10 mumol/l for 30 sec). There were no differences between all the tested ADP and collagen concentrations with regard to platelet aggregation. c-AMP levels were also similar. Thus, in patients with unstable angina there was no evidence for generalized hyperaggregation of platelets in comparison with control subjects who had stable exercise-dependent angina.
在一项前瞻性研究中，对36例冠心病患者进行了检测，其中18例在采血前8小时内有静息性心绞痛，18例有稳定的运动性心绞痛，年龄和性别相匹配。测量了富血小板血浆在ADP刺激（0.5、1.0和10 μmol/l）和胶原蛋白（1和5 μg/ml）后血小板的聚集情况。此外，在前列腺素E1（10 μmol/l，持续30秒）刺激该酶之前和之后（作为血小板腺苷酸环化酶活性的指标）测定了c-AMP。就血小板聚集而言，所有测试的ADP和胶原蛋白浓度之间没有差异。c-AMP水平也相似。因此，与患有稳定运动性心绞痛的对照受试者相比，不稳定型心绞痛患者没有证据表明血小板普遍过度聚集。
