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DLC1: a tumor suppressor that regulates Rho signaling.

作者信息

Tripathi Brajendra K, Lowy Douglas R

机构信息

Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

出版信息

Oncotarget. 2017 Apr 25;8(17):27674-27675. doi: 10.18632/oncotarget.16805.

DOI:10.18632/oncotarget.16805
PMID:28402946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438599/
Abstract
摘要

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DLC1: a tumor suppressor that regulates Rho signaling.DLC1：一种调节Rho信号传导的肿瘤抑制因子。
Oncotarget. 2017 Apr 25;8(17):27674-27675. doi: 10.18632/oncotarget.16805.
2
CDK5 is a major regulator of the tumor suppressor DLC1.细胞周期蛋白依赖性激酶5（CDK5）是肿瘤抑制因子DLC1的主要调节因子。
J Cell Biol. 2014 Dec 8;207(5):627-42. doi: 10.1083/jcb.201405105. Epub 2014 Dec 1.
3
Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation.肝癌缺失 1 肿瘤抑制因子的蛋白-蛋白相互作用和磷酸化调节。
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4
Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading.肝癌缺失基因-1和粘着斑激酶在细胞早期铺展过程中对粘着斑处桩蛋白动力学的协同调节作用
Cytoskeleton (Hoboken). 2014 Dec;71(12):677-94. doi: 10.1002/cm.21201. Epub 2015 Jan 31.
5
The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.肿瘤抑制蛋白 DLC1 通过 PKD 介导的 GAP 结构域磷酸化进行调控。
Exp Cell Res. 2011 Feb 15;317(4):496-503. doi: 10.1016/j.yexcr.2010.11.003. Epub 2010 Nov 16.
6
Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.肝癌缺失的Rho GTP酶激活蛋白抑制肝细胞癌的细胞增殖和侵袭。
Cancer Res. 2005 Oct 1;65(19):8861-8. doi: 10.1158/0008-5472.CAN-05-1318.
7
Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1.RhoA的受体酪氨酸激酶激活是由DLC1的AKT磷酸化介导的。
J Cell Biol. 2017 Dec 4;216(12):4255-4270. doi: 10.1083/jcb.201703105. Epub 2017 Nov 7.
8
DLC1 induces expression of E-cadherin in prostate cancer cells through Rho pathway and suppresses invasion.DLC1 通过 Rho 通路诱导前列腺癌细胞中 E-钙黏蛋白的表达，并抑制侵袭。
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Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathway.肝癌缺失基因1通过依赖Dia1的信号通路调控细胞迁移。
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10
The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.RhoGAP DLC1的SAM结构域与EF1A1结合以调节细胞迁移。
J Cell Sci. 2009 Feb 1;122(Pt 3):414-24. doi: 10.1242/jcs.027482.

引用本文的文献

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DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA.DLC1 SAM结构域结合肽通过使RhoA失活来抑制癌细胞的生长和迁移。
J Biol Chem. 2020 Jan 10;295(2):645-656. doi: 10.1074/jbc.RA119.011929. Epub 2019 Dec 5.
2
Brajendra Tripathi: Keeping an eye out for translational research.Brajendra Tripathi：关注转化研究。
J Cell Biol. 2019 Oct 7;218(10):3161-3162. doi: 10.1083/jcb.201908117. Epub 2019 Sep 12.
3
Estrogen receptor signaling is reprogrammed during breast tumorigenesis.雌激素受体信号在乳腺癌发生过程中被重新编程。
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11437-11443. doi: 10.1073/pnas.1819155116. Epub 2019 May 20.
4
High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.SMARCA4 或 SMARCA2 的高表达常与癌症的预后相反相关。
Sci Rep. 2018 Feb 1;8(1):2043. doi: 10.1038/s41598-018-20217-3.

本文引用的文献

1
Regulating Rho GTPases and their regulators.调节 Rho GTPases 及其调节因子。
Nat Rev Mol Cell Biol. 2016 Aug;17(8):496-510. doi: 10.1038/nrm.2016.67. Epub 2016 Jun 15.
2
DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.DLC1是几种癌症中主要的生物学相关下调的DLC家族成员。
Oncotarget. 2016 Jul 19;7(29):45144-45157. doi: 10.18632/oncotarget.9266.
3
CDK5 is a major regulator of the tumor suppressor DLC1.细胞周期蛋白依赖性激酶5（CDK5）是肿瘤抑制因子DLC1的主要调节因子。
J Cell Biol. 2014 Dec 8;207(5):627-42. doi: 10.1083/jcb.201405105. Epub 2014 Dec 1.
4
Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading.肝癌缺失基因-1和粘着斑激酶在细胞早期铺展过程中对粘着斑处桩蛋白动力学的协同调节作用
Cytoskeleton (Hoboken). 2014 Dec;71(12):677-94. doi: 10.1002/cm.21201. Epub 2015 Jan 31.
5
GAP-independent functions of DLC1 in metastasis.DLC1在转移中不依赖GAP的功能。
Cancer Metastasis Rev. 2014 Mar;33(1):87-100. doi: 10.1007/s10555-013-9458-0.
6
Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation.肝癌缺失 1 肿瘤抑制因子的蛋白-蛋白相互作用和磷酸化调节。
Int J Cancer. 2014 Jul 15;135(2):264-9. doi: 10.1002/ijc.28505. Epub 2013 Oct 17.
7
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.DLC-1是一种具有肿瘤抑制功能的Rho GTP酶激活蛋白，对胚胎发育至关重要。
FEBS Lett. 2005 Feb 14;579(5):1191-6. doi: 10.1016/j.febslet.2004.12.090. Epub 2005 Jan 19.