Dušková Jaroslava, Goldová Barbara, Matiášková Lenka, Beková Alena, Skřenková Jana
Institute of Pathology, 1st Faculty of Medicine, Charles University and Faculty General Hospital, Prague, Czech Republic.
Acta Cytol. 2017;61(2):125-132. doi: 10.1159/000470898. Epub 2017 Apr 13.
To study the contribution of hormonal cytology in contemporary disturbances of fertility.
Over a 10-year period (2006-2015), 6,688 vaginal fornix cytologies of 2,350 patients were investigated. For a more detailed analysis, a 3-year period from 2013 to 2015 was chosen. Four hundred and fifty-two patients were investigated, many of them several times and for a period longer than the 3 years analyzed.
The main disorders examined and treated via a gentle hormonal medication support and life style corrections by a pediatric gynecologist were: pubertas praecox - thelarche praecox and early menarche; dysfunctional juvenile metrorrhagia; central and peripheral endocrine disorders; eating disorders - anorexia mentalis and bulimia; obesity; excessive sport activities; autoimmune disorders, and others. Normalization of the menstrual cycle was achieved while monitoring progress with a series of hormonal cytologies in a majority of patients.
Hormonal cytology is a non-invasive and economical method, illustrating the direct effect of steroid on target cells. It contributes to reproductive health support by: (a) indicating the possible need and type of steroid therapy; (b) monitoring the normalization of cycle disturbances; (c) ruling out or indicating the need for more detailed steroid metabolism investigation. Thus, it represents a basic but valuable means of examination in child and adolescent gynecology.
研究激素细胞学在当代生育障碍中的作用。
在10年期间（2006 - 2015年），对2350例患者的6688份阴道穹窿细胞学样本进行了研究。为了进行更详细的分析，选取了2013年至2015年的3年时间段。对452例患者进行了调查，其中许多患者接受了多次检查，且检查时间超过了所分析的3年。
通过儿科妇科医生采用温和的激素药物支持及生活方式调整来检查和治疗的主要病症包括：性早熟——乳房过早发育和初潮过早；功能性青少年子宫出血；中枢性和外周性内分泌紊乱；饮食失调——神经性厌食和贪食症；肥胖；过度体育活动；自身免疫性疾病等。在大多数患者中，通过一系列激素细胞学监测病情进展的同时实现了月经周期的正常化。
激素细胞学是一种非侵入性且经济的方法，可说明类固醇对靶细胞的直接作用。它通过以下方式有助于生殖健康支持：（a）指明类固醇治疗的可能需求和类型；（b）监测周期紊乱的正常化；（c）排除或指明是否需要进行更详细的类固醇代谢研究。因此，它是儿童和青少年妇科检查的一种基本但有价值的手段。
