a Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University , Chandigarh , India.
b Postgraduate Institute of Medical Education and Research , Chandigarh , India.
Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):346-354. doi: 10.1080/21691401.2017.1313262. Epub 2017 Apr 12.
The present study was aimed to develop and evaluate a microemulsion-based dermal drug delivery of an antiviral agent, acyclovir. A water-in-oil microemulsion was prepared using isopropyl myristate, Tween 20, Span 20, water and dimethylsulphoxide. It was characterized for drug content, stability, globule size, pH, viscosity and ex vivo permeation through mice skin. In vivo antiviral efficacy of optimized formulation was assessed in female Balb/c mice against herpes simplex virus-I (HSV-I)-induced infection. It was observed that optimized formulation when applied 24-h post-infection could completely inhibit the development of cutaneous herpetic lesions vis-à-vis marketed cream.
本研究旨在开发和评价一种基于微乳的抗病毒药物阿昔洛韦的经皮给药系统。采用肉豆蔻酸异丙酯、吐温 20、司盘 20、水和二甲基亚砜制备水包油型微乳。对其药物含量、稳定性、粒径、pH 值、黏度和体外经小鼠皮肤渗透进行了评价。在雌性 Balb/c 小鼠中，对优化后的制剂进行了针对单纯疱疹病毒 I（HSV-I）诱导感染的体内抗病毒功效评估。结果表明，与市售乳膏相比，优化后的制剂在感染后 24 小时给药时可完全抑制皮肤疱疹病变的发展。
