Moody T W, Lebovic G S, Carney D N, Korman L Y
Biochemistry Department, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037.
Int J Neurosci. 1988 May;40(1-2):141-8. doi: 10.3109/00207458808985735.
BN/GRP-like peptides are produced in high concentrations in SCLC cell lines and in low concentrations in beta-lymphoblastoid cell lines. The BN/GRP-like peptides are secreted from SCLC cell line NCI-H345 by stimuli which elevate the intracellular cAMP levels. These stimuli include theophylline, PHI, secretin and VIP. Also, elevated plasma levels of BN/GRP-like peptides are found in patients with extensive SCLC. In these patients the levels of BN/GRP-like peptides can be increased further approximately 5-fold after secretin infusion. Because SCLC cells make and secrete BN/GRP-like peptides, they may function as regulatory peptides in this disease.
类BN/GRP肽在小细胞肺癌细胞系中高浓度产生，而在β-淋巴母细胞系中低浓度产生。类BN/GRP肽由小细胞肺癌细胞系NCI-H345在能提高细胞内cAMP水平的刺激下分泌。这些刺激包括茶碱、PHI、促胰液素和血管活性肠肽。此外，广泛期小细胞肺癌患者血浆中类BN/GRP肽水平升高。在这些患者中，促胰液素输注后类BN/GRP肽水平可进一步升高约5倍。由于小细胞肺癌细胞产生并分泌类BN/GRP肽，它们可能在这种疾病中发挥调节肽的作用。
