肾小球健康与疾病中足细胞生物学的新见解
New Insights into Podocyte Biology in Glomerular Health and Disease.
作者信息
Assady Suheir, Wanner Nicola, Skorecki Karl L, Huber Tobias B
机构信息
Department of Nephrology and Hypertension, Rambam Health Care Campus, Haifa, Israel.
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
出版信息
J Am Soc Nephrol. 2017 Jun;28(6):1707-1715. doi: 10.1681/ASN.2017010027. Epub 2017 Apr 12.
Abstract
Podocyte and glomerular research is center stage for the development of improved preventive and therapeutic strategies for chronic progressive kidney diseases. Held April 3-6, 2016, the 11th International Podocyte Conference took place in Haifa and Jerusalem, Israel, where participants from all over the world presented their work on new developments in podocyte research. In this review, we briefly highlight the advances made in characterizing the mechanisms involved in podocyte development, metabolism, acquired injury, and repair, including progress in determining the roles of genetic variants and microRNA in particular, as well as the advances made in diagnostic techniques and therapeutics.
摘要
足细胞与肾小球研究是慢性进行性肾脏疾病预防和治疗策略改进发展的核心领域。2016年4月3日至6日，第11届国际足细胞会议在以色列海法和耶路撒冷举行，来自世界各地的参会者展示了他们在足细胞研究新进展方面的工作。在本综述中，我们简要强调了在足细胞发育、代谢、获得性损伤和修复相关机制的特征描述方面取得的进展，包括特别是在确定基因变异和微小RNA作用方面取得的进展，以及诊断技术和治疗方面取得的进展。
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