丹参酮IIA通过抑制氧化应激和炎症减轻链脲佐菌素诱导的糖尿病大鼠的肾损伤。
Tanshinone IIA attenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation.
作者信息
Chen Xia, Wu Rui, Kong Yiwei, Yang Yuting, Gao Yu, Sun Dandan, Liu Qizhen, Dai Dongjun, Lu Zeyuan, Wang Niansong, Ge Sheng, Wang Feng
机构信息
Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Department of Clinical Nutrition, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
出版信息
Oncotarget. 2017 May 9;8(19):31915-31922. doi: 10.18632/oncotarget.16651.
Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN.
氧化应激和炎症已被证明与糖尿病肾病（DN）的发生和发展有关。丹参酮IIA（Tan）具有抗氧化和抗炎特性。在此，本研究的目的是探讨Tan是否能减轻链脲佐菌素（STZ）诱导的糖尿病大鼠的肾损伤及其潜在机制。以10mg/kg的剂量每天一次给STZ诱导的糖尿病大鼠灌胃Tan，持续12周。Tan治疗显著减轻了糖尿病大鼠的蛋白尿和肾脏组织病理学变化。此外，Tan治疗还有效抑制了糖尿病大鼠肾脏中的氧化应激和炎症反应。我们的研究提供了证据，表明Tan对糖尿病诱导的肾损伤的保护作用与抑制氧化应激和炎症有关。Tan可能是治疗DN的潜在候选药物。
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