糖尿病肾病中的表观遗传调控
Epigenetic Regulations in Diabetic Nephropathy.
作者信息
Lu Zeyuan, Liu Na, Wang Feng
机构信息
Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
出版信息
J Diabetes Res. 2017;2017:7805058. doi: 10.1155/2017/7805058. Epub 2017 Mar 19.
Abstract
Diabetic nephropathy (DN) is a chronic complication of diabetes and the most common cause of end-stage kidney disease. It has been reported that multiple factors are involved in the pathogenesis of DN, while the molecular mechanisms that lead to DN are still not fully understood. Numerous risk factors for the development of diabetic nephropathy have been proposed, including ethnicity and inherited genetic differences. Recently, with the development of high-throughput technologies, there is emerging evidence that suggests the important role of epigenetic mechanisms in the pathogenesis of DN. Epigenetic regulations, including DNA methylation, noncoding RNAs, and histone modifications, play a pivotal role in DN pathogenesis by a second layer of gene regulation. All these findings can contribute to developing novel therapies for DN.
摘要
糖尿病肾病（DN）是糖尿病的一种慢性并发症，也是终末期肾病最常见的病因。据报道，DN的发病机制涉及多种因素，但导致DN的分子机制仍未完全明确。已经提出了许多糖尿病肾病发生发展的危险因素，包括种族和遗传基因差异。最近，随着高通量技术的发展，越来越多的证据表明表观遗传机制在DN发病机制中发挥重要作用。表观遗传调控，包括DNA甲基化、非编码RNA和组蛋白修饰，通过第二层基因调控在DN发病机制中起关键作用。所有这些发现都有助于开发针对DN的新疗法。
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