Verma Versha, Rana Shelly, Chaudhary Sudarshan Kumar, Singh Jai, Verma Ravinder Kumar, Sood Saloni
Department of Anaesthesia, DRPGMC, Tanda, Himachal Pradesh, India.
Indian J Anaesth. 2017 Mar;61(3):250-255. doi: 10.4103/ija.IJA_466_16.
Magnesium sulphate (MgSO) has been used as an adjuvant in brachial plexus block with encouraging results; however, there is no consensus regarding its optimal dose. Thereby, we compared the efficacy of two doses of MgSO as an adjuvant in ultrasound (USG) guided supraclavicular brachial plexus block.
Ninety patients, aged 20-60 years, belonging to American Society of Anesthesiologists physical status 1 or 2, were given USG-guided supraclavicular block. Group B ( = 30) received 20 ml of 0.5%bupivacaine + 5 ml normal saline (NS), Group BM( = 30) received 20 ml of 0.5%bupivacaine + 3.75 ml NS and 125 mg MgSO (1.25 ml) and Group BM( = 30) received 20 ml of 0.5%bupivacaine + 2.5 ml NS and 250 mg MgSO (2.5 ml). The primary outcome of study was the duration of post-operative analgesia. The normally distributed data were analysed using analysis of variance and categorical data analysed using Chi-square test.
Duration of post-operative analgesia was prolonged in Groups BM and BM (665.13 ± 97.874, 475.10 ± 53.294) min respectively as compared to Group B (272.03 ± 40.404 min: = 0.00). The onset times of sensory and motor block were shorter in Group BM (5.17 ± 2.2 min) as compared to Groups BM and B (8.9 ± 2.3 and 17.7 ± 5.1 min: = 0.00) respectively. Sensory and motor block durations were prolonged in Group BM as compared to BM and B ( = 0.00).
MgSO as adjuvant in brachial plexus block increases the duration of post-operative analgesia. MgSO in the dose of 250mg has greater efficacy as compared to 125 mg.
硫酸镁（MgSO）已被用作臂丛神经阻滞的辅助药物，效果令人鼓舞；然而，关于其最佳剂量尚无共识。因此，我们比较了两种剂量的MgSO作为辅助药物在超声（USG）引导下锁骨上臂丛神经阻滞中的疗效。
90例年龄在20 - 60岁、美国麻醉医师协会身体状况分级为1或2级的患者接受了USG引导下的锁骨上阻滞。B组（n = 30）接受20 ml 0.5%布比卡因 + 5 ml生理盐水（NS），BM1组（n = 30）接受20 ml 0.5%布比卡因 + 3.75 ml NS和125 mg MgSO（1.25 ml），BM2组（n = 30）接受20 ml 0.5%布比卡因 + 2.5 ml NS和250 mg MgSO（2.5 ml）。研究的主要结局是术后镇痛的持续时间。正态分布数据采用方差分析，分类数据采用卡方检验进行分析。
与B组（272.03 ± 40.404分钟：P = 0.00）相比，BM1组和BM2组术后镇痛持续时间分别延长（665.13 ± 97.874，475.10 ± 53.294）分钟。与BM2组和B组（分别为8.9 ± 2.3和17.7 ± 5.1分钟：P = 0.00）相比，BM1组感觉和运动阻滞的起效时间更短（5.17 ± 2.2分钟）。与BM2组和B组相比，BM1组感觉和运动阻滞持续时间延长（P = 0.00）。
MgSO作为臂丛神经阻滞的辅助药物可延长术后镇痛时间。250mg剂量的MgSO比125mg具有更大的疗效。
