儿茶酚雌激素加合物

Catechol estrogen adducts.

作者信息

Abul-Hajj Y J, Cisek P L

机构信息

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.

出版信息

J Steroid Biochem. 1988 Jul;31(1):107-10. doi: 10.1016/0022-4731(88)90212-9.

DOI:10.1016/0022-4731(88)90212-9

PMID:2840531

Abstract

Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-2 of 4-hydroxyestrone.

摘要

雌酮 -3,4 -邻醌与乙硫醇和谷胱甘肽反应生成4 -羟基雌酮 -2 -硫醚。在谷胱甘肽存在的情况下，将[1 - ³H]羟基雌酮与大鼠肝微粒体和NADPH一起温育，会形成4 -羟基雌酮 -S -谷胱甘肽，且水中没有³H释放，这表明谷胱甘肽加成到了4 -羟基雌酮的C -2位。