Savage D D, Mills S A, Jobe P C, Reigel C E
Department of Pharmacology, University of New Mexico School of Medicine, Albuquerque 87131.
Life Sci. 1988;43(3):239-46. doi: 10.1016/0024-3205(88)90313-x.
3H-Dihydromorphine (DHM) binding sites were measured in the brain of non-epileptic control and GEPR rats using in vitro autoradiographic techniques. The number of naloxone-sensitive 3H-DHM binding sites was increased 38-57% in the pyramidal cell layer of ventral hippocampal CA3 and Ca1 of GEPR-3 and GEPR-9 rats compared to non-epileptic controls. No significant differences in 3H-DHM binding were observed in dorsal hippocampal formation, lateral entorhinal cortex, lateral geniculate or cerebellum. The results suggest that an increase in the number of opioid receptors in ventral hippocampus of GEPR rats may be one factor contributing to the enhanced sensitivity of GEPR-9 rats to the proconvulsant effects of morphine.
采用体外放射自显影技术，在非癫痫对照大鼠和遗传癫痫易感大鼠（GEPR）的大脑中测量了3H-二氢吗啡（DHM）结合位点。与非癫痫对照大鼠相比，GEPR-3和GEPR-9大鼠腹侧海马CA3和CA1锥体细胞层中纳洛酮敏感的3H-DHM结合位点数量增加了38%-57%。在背侧海马结构、外侧内嗅皮质、外侧膝状体或小脑中未观察到3H-DHM结合的显著差异。结果表明，GEPR大鼠腹侧海马中阿片受体数量的增加可能是导致GEPR-9大鼠对吗啡惊厥作用敏感性增强的因素之一。
