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伤寒热后双侧视网膜炎。

Bilateral retinitis following typhoid fever.

作者信息

Prabhushanker M, Topiwalla Tasneem T, Ganesan Geetha, Appandaraj Sripal

机构信息

Sankara Eye Centre, Sathy Road, Sivanandapuram, Coimbatore, 641035 India.

出版信息

Int J Retina Vitreous. 2017 Apr 10;3:11. doi: 10.1186/s40942-017-0065-z. eCollection 2017.

DOI:10.1186/s40942-017-0065-z
PMID:28405476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5385597/
Abstract

BACKGROUND

Post typhoid fever immune related reactions affecting the eye is a rare finding which can have various presentations in which typhoid retinopathy is not a well recognized sequelae.

CASE PRESENTATION

Here we present a case of 59 year old male who presented with right eye sudden painless loss of vision 4 weeks after typhoid fever which was diagnosed and treated successfully. His BCVA was 2/60 in right eye and 6/6 in left eye. Fundus examination showed retinitis along with macular serous detachment in right eye and retinitis in left eye. Significant improvement in BCVA in right eye was observed after treatment with oral steroid with resolving retinitis lesions. Diagnosis of post typhoid immune mediated retinitis was made with good resolution following treatment.

CONCLUSIONS

Immune mediated retinitis is a rare sequelae to typhoid infection which can be successfully treated with systemic steroids with good resolution of the lesions.

摘要

背景

伤寒热后影响眼睛的免疫相关反应是一种罕见的发现,可有多种表现形式,其中伤寒性视网膜病变并非一种广为人知的后遗症。

病例报告

我们在此报告一例59岁男性,在患伤寒热4周后出现右眼突然无痛性视力丧失,经诊断并成功治疗。他右眼的最佳矫正视力(BCVA)为2/60,左眼为6/6。眼底检查显示右眼有视网膜炎伴黄斑浆液性脱离,左眼有视网膜炎。口服类固醇治疗后,右眼的BCVA有显著改善,视网膜炎病变消退。经治疗后,诊断为伤寒后免疫介导性视网膜炎,病变得到良好缓解。

结论

免疫介导性视网膜炎是伤寒感染的一种罕见后遗症,可通过全身用类固醇成功治疗,病变能得到良好缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde7/5385597/c404177fc19b/40942_2017_65_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde7/5385597/076e162b194c/40942_2017_65_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde7/5385597/ec89a748777c/40942_2017_65_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde7/5385597/c404177fc19b/40942_2017_65_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde7/5385597/076e162b194c/40942_2017_65_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde7/5385597/ec89a748777c/40942_2017_65_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde7/5385597/c404177fc19b/40942_2017_65_Fig3_HTML.jpg

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本文引用的文献

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2
The pathology and pathogenesis of retinal vasculitis.视网膜血管炎的病理学与发病机制。
Neuropathol Appl Neurobiol. 2003 Aug;29(4):325-40. doi: 10.1046/j.1365-2990.2003.00499.x.
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Stellate maculopathy due to Salmonella typhi. A case report.
发热性视网膜炎患者玻璃体中的真菌群落变化。
PLoS One. 2020 Nov 19;15(11):e0242138. doi: 10.1371/journal.pone.0242138. eCollection 2020.
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Post-fever retinitis - Newer concepts.发热后性视网膜炎——新概念。
Indian J Ophthalmol. 2020 Sep;68(9):1775-1786. doi: 10.4103/ijo.IJO_1352_20.
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Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever.美罗培南治疗反应延迟后伤寒热复发:一例病例报告及对既往发表病例的回顾,提示美罗培南治疗伤寒热的临床疗效有限
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