Kumaran Muthu Sendhil, Mangal Sonia, Narang Tarun, Parsad Davinder
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian Dermatol Online J. 2017 Mar-Apr;8(2):94-99. doi: 10.4103/2229-5178.202266.
The objective of this study was to assess autologous serum skin test (ASST) vs autologous plasma skin test (APST) response in chronic spontaneous urticaria (CSU) patients and study the significance of intensity of positive responses in relation to clinicoepidemiological parameters.
One hundred CSU patients and 100 age and sex-matched controls were recruited. The demographic and clinical features were recorded in all patients and routine investigations were performed. ASST and APST tests were performed as per the standard guidelines.
The mean duration of illness was 4.85 ± 5.07 years, 90% patients were APST (+), 68% ASST (+), and 22 patients were only APST (+). Positive predictive value (PPV) of ASST and APST was 90.7% and 95.7%, respectively. A significant inverse association was seen between thyroid status and serum IgE levels with APST and ASST positivity.
APST appears to have better PPV and high intensity of positive response on autologous tests, and correlates with ANA positivity and angioedema.
本研究的目的是评估慢性自发性荨麻疹（CSU）患者的自体血清皮肤试验（ASST）与自体血浆皮肤试验（APST）反应，并研究阳性反应强度与临床流行病学参数的相关性。
招募了100例CSU患者和100例年龄及性别匹配的对照者。记录所有患者的人口统计学和临床特征，并进行常规检查。按照标准指南进行ASST和APST试验。
平均病程为4.85±5.07年，90%的患者APST阳性，68%的患者ASST阳性，22例患者仅APST阳性。ASST和APST的阳性预测值（PPV）分别为90.7%和95.7%。甲状腺状态和血清IgE水平与APST和ASST阳性之间存在显著的负相关。
APST在自体试验中似乎具有更好的PPV和较高的阳性反应强度，并且与抗核抗体阳性和血管性水肿相关。
