Blethen S L
Division of Pediatric Endocrinology, Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, N.Y.
Pediatrician. 1987;14(4):242-5.
Although most children with craniopharyngiomas have multiple hormone deficiencies, some will have normal growth with hyperphagia and obesity postoperatively. Many later fail to maintain this growth. If growth hormone (GH) treatment is not instituted at this time, adult height will be compromised. Normal or accelerated growth following surgery does not indicate the presence of normal GH secretion nor insure continued growth. Children with this syndrome should have careful follow-up with accurate growth measurements so that GH replacement therapy can begin when indicated.
尽管大多数颅咽管瘤患儿存在多种激素缺乏,但有些患儿术后会出现食欲亢进和肥胖,生长正常。许多患儿后来无法维持这种生长状态。如果此时不开始生长激素(GH)治疗,成年身高将会受到影响。术后正常或加速生长并不表明存在正常的GH分泌,也不能保证持续生长。患有这种综合征的儿童应进行仔细随访,并进行准确的生长测量,以便在有指征时开始GH替代治疗。