APR-246/PRIMA-1抑制硫氧还蛋白还原酶1，并将该酶转化为一种特定的NADPH氧化酶。 - Suppr

APR-246/PRIMA-1 inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

作者信息

Peng Xiaoxiao, Zhang Mei-Qiong-Zi, Conserva Francesca, Hosny Gihan, Selivanova Galina, Bykov Vladimir Jn, Arnér Elias Sj, Wiman Klas G

出版信息

Cell Death Dis. 2017 Apr 13;8(4):e2751. doi: 10.1038/cddis.2016.137.

DOI:10.1038/cddis.2016.137

PMID:28406483

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5477569/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1237/5477569/b484ab02cfeb/cddis2016137f3.jpg

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APR-246/PRIMA-1 inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.APR-246/PRIMA-1抑制硫氧还蛋白还原酶1，并将该酶转化为一种特定的NADPH氧化酶。

Cell Death Dis. 2017 Apr 13;8(4):e2751. doi: 10.1038/cddis.2016.137.

The NADPH thioredoxin reductase C functions as an electron donor to 2-Cys peroxiredoxin in a thermophilic cyanobacterium Thermosynechococcus elongatus BP-1.在嗜热蓝藻细长聚球藻BP-1中，NADPH硫氧还蛋白还原酶C作为电子供体作用于2-半胱氨酸过氧化物酶。

Biochem Biophys Res Commun. 2009 Mar 13;380(3):520-4. doi: 10.1016/j.bbrc.2009.01.091. Epub 2009 Jan 23.

Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis.大肠杆菌硫氧还蛋白还原酶的晶体结构在2埃分辨率下的精修。催化过程中发生大构象变化的意义。

J Mol Biol. 1994 Feb 25;236(3):800-16.

Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution.拟南芥NADPH依赖型硫氧还蛋白还原酶在2.5埃分辨率下的晶体结构。

J Mol Biol. 1996 Dec 20;264(5):1044-57. doi: 10.1006/jmbi.1996.0695.

A 35 kDa NAD(P)H oxidase previously isolated from the archaeon Sulfolobus solfataricus is instead a thioredoxin reductase.先前从嗜热栖热菌中分离出的一种35 kDa烟酰胺腺嘌呤二核苷酸磷酸（NAD(P)H）氧化酶，实际上是一种硫氧还蛋白还原酶。

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The activity of barley NADPH-dependent thioredoxin reductase C is independent of the oligomeric state of the protein: tetrameric structure determined by cryo-electron microscopy.大麦 NADPH 依赖型硫氧还蛋白还原酶 C 的活性不依赖于蛋白质的寡聚状态：通过冷冻电子显微镜确定的四聚体结构。

Biochemistry. 2011 May 10;50(18):3713-23. doi: 10.1021/bi200058a. Epub 2011 Apr 15.

The quaternary structure of NADPH thioredoxin reductase C is redox-sensitive.NADPH 硫氧还蛋白还原酶 C 的四元结构对氧化还原敏感。

Mol Plant. 2009 May;2(3):457-67. doi: 10.1093/mp/ssp011. Epub 2009 Mar 26.

Thioredoxin reductase-thioredoxin fusion enzyme from Mycobacterium leprae: comparison with the separately expressed thioredoxin reductase.来自麻风分枝杆菌的硫氧还蛋白还原酶-硫氧还蛋白融合酶：与单独表达的硫氧还蛋白还原酶的比较。

Biochemistry. 1998 Nov 17;37(46):16378-89. doi: 10.1021/bi980754e.

Kinetic evidence that methionine sulfoxide reductase A can reveal its oxidase activity in the presence of thioredoxin.在硫氧还蛋白存在的情况下，甲硫氨酸亚砜还原酶 A 可以揭示其氧化酶活性的动力学证据。

Arch Biochem Biophys. 2014 Apr 15;548:54-9. doi: 10.1016/j.abb.2014.03.002. Epub 2014 Mar 13.

A proposed reaction mechanism for rice NADPH thioredoxin reductase C, an enzyme with protein disulfide reductase activity.水稻NADPH硫氧还蛋白还原酶C（一种具有蛋白质二硫键还原酶活性的酶）的一种推测反应机制。

FEBS Lett. 2009 May 6;583(9):1399-402. doi: 10.1016/j.febslet.2009.03.067. Epub 2009 Apr 5.

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APR-246/PRIMA-1 inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

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