磷脂模拟奥沙利铂前药脂质体治疗转移性三阴性乳腺癌。
Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer.
机构信息
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
University of Chinese Academy of Sciences, Beijing 100049, China and Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
Biomater Sci. 2017 Jul 25;5(8):1522-1525. doi: 10.1039/c7bm00058h.
A phospholipid-mimic oxaliplatin prodrug (Oxalipid) was synthesized, which could self-assemble into a liposomal nanostructure with a drug loading ratio as high as 27 wt%. Compared to free oxaliplatin, the resulting Oxalipid liposome displayed elongated blood circulation, increased tumor accumulation and improved anticancer efficacy against the metastatic triple negative breast cancer (TNBC).
合成了一种模拟磷脂的奥沙利铂前药（Oxalipid），它可以自组装成载药率高达 27wt%的脂质体纳米结构。与游离奥沙利铂相比，所得 Oxalipid 脂质体具有延长的血液循环时间、增加肿瘤积累和提高对转移性三阴性乳腺癌（TNBC）的抗癌疗效。
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