Burhop Annina, Prohaska Raphail, Weck Remo, Atzrodt Jens, Derdau Volker
Integrated Drug Discovery, Med. Chem., Isotope Chemistry and Metabolite Synthesis, Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
J Labelled Comp Radiopharm. 2017 Jun 15;60(7):343-348. doi: 10.1002/jlcr.3512. Epub 2017 May 12.
We have evaluated the commercially available Burgess catalyst in hydrogen isotope exchange reactions with several substrates bearing different directing group functionalities and have obtained moderate to high (50%-97%D) deuterium incorporations. The broad applicability in hydrogen isotope exchange reactions makes the Burgess catalyst a possible alternative compared to other commercially available iridium(I)-catalysts.
我们评估了市售的伯吉斯催化剂在与几种带有不同导向基团功能的底物进行氢同位素交换反应中的性能，获得了中等至较高（50%-97%D）的氘掺入率。伯吉斯催化剂在氢同位素交换反应中的广泛适用性使其成为与其他市售铱（I）催化剂相比的一种可能选择。
