Department of Chemistry, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Org Lett. 2017 May 5;19(9):2350-2353. doi: 10.1021/acs.orglett.7b00882. Epub 2017 Apr 13.
A general, radical-mediated approach to quaternary center construction using unactivated alkenes as coupling partners is reported. In this strategy, acyl xanthates, readily accessed from carboxylic acids, serve as precursors to tertiary radicals. This strategy leverages the unique reactivity of xanthates to participate in efficient radical-mediated additions to unactivated alkenes, expanding the scope of quaternary center construction.
本文报道了一种使用未活化烯烃作为偶联伙伴构建季碳原子中心的通用、自由基介导方法。在该策略中，酰基黄原酸盐可从羧酸中轻易获得，作为叔自由基的前体。该策略利用黄原酸盐的独特反应性，有效地促进自由基介导的未活化烯烃加成反应，从而扩展了季碳原子中心构建的范围。
