Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.
Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
JPEN J Parenter Enteral Nutr. 2018 Mar;42(3):522-528. doi: 10.1177/0148607117703959. Epub 2017 Dec 12.
Misconnections between enteral supplies and other access devices have led to significant morbidity and mortality. To reduce misconnections, a standard small-bore connector has been developed (International Organization for Standards 80369-8; ENFit). The full impact of transition to this connector is not known, however.
Working with major manufacturers and Food and Drug Administration, we obtained ENFit and comparative legacy tubes of variable sizes (low-profile, 14F, 18F, 20F, and 24F balloon gastrostomies). Gravity enteral feeding was simulated with an empty bolus syringe attached to the feeding tube to be tested. The tube was clamped and filled to the 60-mL mark with liquid (water, Jevity 1 Cal, Isosource HN, Isosource 1.5 Cal, Two Cal HN, and Nourish). The clamp was released, and time for formula to leave the syringe was recorded.
There was no difference in flow rate between the aggregate legacy and ENFit tubes for the low-profile, 18F, and 20F sizes. The ENFit 14F tubes had a lower flow rate vs the legacy tubes, largely due to the low flow rates seen with the 1 ENFit tube. Similarly, 24F ENFit tubes with some formulas yielded lower flow rates as opposed to legacy.
Overall, for the low-profile, 18F, and 20F sizes, the ENFit tubes had similar flow rates when compared with the legacy tubes. For the 14F and 24F sizes, the flow rate of ENFit tubes was significantly lower, which could result in longer EN delivery for patients who are using these tubes to provide gravity feeding.
肠内供给品与其他接入设备之间的错误连接导致了重大的发病率和死亡率。为了减少错误连接，已经开发出一种标准的小口径连接器（国际标准化组织 80369-8；ENFit）。然而，完全过渡到这种连接器的影响尚不清楚。
与主要制造商和食品药品监督管理局合作，我们获得了 ENFit 和不同尺寸的传统管（低轮廓，14F，18F，20F 和 24F 球囊胃造口术）。用连接到要测试的喂养管的空弹丸注射器模拟重力肠内喂养。将管夹上并将液体（水，Jevity 1 Cal，Isosource HN，Isosource 1.5 Cal，Two Cal HN 和 Nourish）填充至 60 毫升标记。释放夹子，记录配方离开注射器的时间。
对于低轮廓、18F 和 20F 尺寸，传统管和 ENFit 管的总体流速没有差异。ENFit 14F 管的流速低于传统管，这主要是由于 1 个 ENFit 管的流速较低。同样，与传统管相比，一些配方的 24F ENFit 管的流速较低。
总体而言，对于低轮廓、18F 和 20F 尺寸，ENFit 管的流速与传统管相似。对于 14F 和 24F 尺寸，ENFit 管的流速明显较低，这可能导致使用这些管提供重力喂养的患者的 EN 输送时间更长。
