Ren Weicheng, Li Wei, Ye Xiaofei, Liu Hui, Pan-Hammarström Qiang
aDivision of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden bKey Laboratory of Cancer Prevention and Therapy, Department of Lymphoma, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Curr Opin Hematol. 2017 Jul;24(4):367-376. doi: 10.1097/MOH.0000000000000355.
Here, we give an updated overview of the subtype distribution of lymphomas in East Asia and also present the genome sequencing data on two major subtypes of these tumors.
The distribution of lymphoma types/subtypes among East Asian countries is very similar, with a lower proportion of B-cell malignancies and a higher proportion of T/natural killer (NK)-cell lymphomas as compared to Western populations. Extranodal NK/T-cell lymphoma is more frequently observed in East Asia, whereas follicular lymphoma and chronic lymphocytic leukemia, are proportionally lower. The incidence rate of lymphoma subtypes in Asians living in the US was generally intermediate to the general rate in US and Asia, suggesting that both genetic and environmental factors may underlie the geographical variations observed.Key cancer driver mutations have been identified in Asian patients with diffuse large B-cell lymphoma or extranodal NK/T-cell lymphoma through genome sequencing. A distinct somatic mutation profile has also been observed in Chinese diffuse large B-cell lymphoma patients.
The incidence and distribution of lymphoma subtypes differed significantly between patients from East Asia and Western countries, suggesting subtype-specific etiologic mechanisms. Further studies on the mechanism underlying these geographical variations may give new insights into our understanding of lymphomagenesis.
在此，我们对东亚淋巴瘤的亚型分布进行了更新概述，并展示了这些肿瘤的两种主要亚型的基因组测序数据。
东亚国家间淋巴瘤类型/亚型的分布非常相似，与西方人群相比，B细胞恶性肿瘤比例较低，T/自然杀伤（NK）细胞淋巴瘤比例较高。结外NK/T细胞淋巴瘤在东亚更为常见，而滤泡性淋巴瘤和慢性淋巴细胞白血病的比例相对较低。生活在美国的亚洲人淋巴瘤亚型的发病率通常介于美国和亚洲的总体发病率之间，这表明遗传和环境因素可能是观察到的地理差异的基础。通过基因组测序，在亚洲弥漫性大B细胞淋巴瘤或结外NK/T细胞淋巴瘤患者中已鉴定出关键的癌症驱动突变。在中国弥漫性大B细胞淋巴瘤患者中也观察到了独特的体细胞突变谱。
东亚患者与西方国家患者的淋巴瘤亚型发病率和分布存在显著差异，提示存在亚型特异性病因机制。对这些地理差异背后机制的进一步研究可能为我们理解淋巴瘤发生提供新的见解。
