Ko Y H, Kim C W, Park C S, Jang H K, Lee S S, Kim S H, Ree H J, Lee J D, Kim S W, Huh J R
Department of Diagnostic Pathology, Samsung Medical Center, Sung Kyun Kwan University, Seoul, Korea.
Cancer. 1998 Aug 15;83(4):806-12.
The clinicopathologic characteristics of malignant lymphomas vary according to geography. The aim of this study was to determine the clinical characteristics of malignant lymphomas and the relative frequency in the Republic of Korea of lymphomas belonging to the newly described REAL (revised European-American lymphoma) classification categories.
The Hematolymphoreticular Study Group of the Korean Society of Pathologists conducted a consensus-based morphologic review of a nationwide collection of 1548 malignant lymphomas, including Hodgkin's disease (HD), diagnosed at 23 institutes over a recent 2-year period. Slides stained with hematoxylin and eosin or other immunohistochemical stains were reviewed. All cases were classified according to the histologic criteria proposed by the International Lymphoma Study Group. Clinical data, including age, gender, and site of disease involvement, were reviewed.
The Republic of Korea had lower rates of HD and follicle center lymphoma and higher rates of extranodal lymphoma, diffuse large B-cell lymphoma, and angiocentric lymphoma compared with Western countries. The most frequent subtypes of non-Hodgkin's lymphoma (NHL) were diffuse large B-cell lymphoma, extranodal marginal zone B-cell lymphoma, peripheral T-cell lymphoma, unspecified type, and angiocentric lymphoma, in decreasing order. Compared with a previous nationwide study, the rates for follicular lymphoma and NHL involving the stomach, orbit, and central nervous system were increased. The rate of T-cell NHL in the current study was much lower than that reported in a previous study for the Republic of Korea and was also lower than that reported for other Far East countries. For HD, the relative frequency of nodular sclerosis subtype was higher compared with that in the previous study, and lymphocyte predominance and lymphocyte depletion were lower.
The occurrence rates for various subtypes of malignant lymphoma in the Republic of Korea are distinct from those in Western countries and similar in many ways to those in other countries in the Far East. Compared with other Far East countries, the Republic of Korea has a higher rate of extranodal lymphoma, rare adult T-cell lymphoma, and a relatively low rate of T-cell lymphomas. It appears that over time there have been changes in the relative rates for follicular lymphoma, subtypes of Hodgkin's disease, and gastric and orbital lymphoma. The authors attribute these changes primarily to refined criteria for diagnosing new clinicopathologic entities.
恶性淋巴瘤的临床病理特征因地域而异。本研究的目的是确定恶性淋巴瘤的临床特征以及韩国新描述的REAL（修订的欧美淋巴瘤）分类类别中淋巴瘤的相对发病率。
韩国病理学家协会血液淋巴网状组织研究组对最近两年内23家机构诊断的1548例恶性淋巴瘤（包括霍奇金病[HD]）进行了基于共识的形态学回顾。对苏木精和伊红染色或其他免疫组化染色的切片进行了复查。所有病例均根据国际淋巴瘤研究组提出的组织学标准进行分类。对临床资料，包括年龄、性别和疾病累及部位进行了复查。
与西方国家相比，韩国的HD和滤泡中心淋巴瘤发病率较低，结外淋巴瘤、弥漫性大B细胞淋巴瘤和血管中心性淋巴瘤发病率较高。非霍奇金淋巴瘤（NHL）最常见的亚型依次为弥漫性大B细胞淋巴瘤、结外边缘区B细胞淋巴瘤、外周T细胞淋巴瘤（未特定类型）和血管中心性淋巴瘤。与之前的全国性研究相比，滤泡性淋巴瘤以及累及胃、眼眶和中枢神经系统的NHL发病率有所增加。本研究中T细胞NHL的发病率远低于韩国之前一项研究报告的发病率，也低于其他远东国家报告的发病率。对于HD，结节硬化亚型的相对发病率高于之前的研究，淋巴细胞为主型和淋巴细胞消减型的发病率较低。
韩国恶性淋巴瘤各亚型的发病率与西方国家不同，在许多方面与其他远东国家相似。与其他远东国家相比，韩国结外淋巴瘤发病率较高，成人T细胞淋巴瘤罕见，T细胞淋巴瘤发病率相对较低。随着时间的推移，滤泡性淋巴瘤、霍奇金病亚型以及胃和眼眶淋巴瘤的相对发病率似乎发生了变化。作者将这些变化主要归因于诊断新的临床病理实体的标准更加精细。
