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本文引用的文献

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Mid-regional pro-atrial natriuretic peptide to predict clinical course in heart failure patients undergoing cardiac resynchronization therapy.中段心房利钠肽预测心力衰竭患者心脏再同步化治疗的临床过程。
Europace. 2017 Nov 1;19(11):1848-1854. doi: 10.1093/europace/euw305.
2
Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.降钙素肽家族成员受 LPS 调控差异，并抑制大鼠肺泡 NR8383 巨噬细胞的功能。
PLoS One. 2016 Oct 13;11(10):e0163483. doi: 10.1371/journal.pone.0163483. eCollection 2016.
3
Adrenomedullin 2 Enhances Beiging in White Adipose Tissue Directly in an Adipocyte-autonomous Manner and Indirectly through Activation of M2 Macrophages.肾上腺髓质素2以脂肪细胞自主的方式直接增强白色脂肪组织的米色化，并通过激活M2巨噬细胞间接增强米色化。
J Biol Chem. 2016 Nov 4;291(45):23390-23402. doi: 10.1074/jbc.M116.735563. Epub 2016 Sep 12.
4
Adrenomedullin2 (ADM2)/Intermedin (IMD): A Potential Role in the Pathophysiology of Preeclampsia.肾上腺髓质素2（ADM2）/中间介质（IMD）：在子痫前期病理生理学中的潜在作用
J Clin Endocrinol Metab. 2016 Nov;101(11):4478-4488. doi: 10.1210/jc.2016-1333. Epub 2016 Sep 1.
5
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.受体活性修饰蛋白对降钙素基因相关肽受体家族的G蛋白信号传导特异性的导向作用
J Biol Chem. 2016 Oct 14;291(42):21925-21944. doi: 10.1074/jbc.M116.751362. Epub 2016 Aug 26.
6
Intermedin/adrenomedullin 2 is a stress-inducible gene controlled by activating transcription factor 4.中间介质/肾上腺髓质素2是一种受激活转录因子4调控的应激诱导基因。
Gene. 2016 Sep 15;590(1):177-85. doi: 10.1016/j.gene.2016.06.037. Epub 2016 Jun 18.
7
Adrenomedullin 2 Improves Early Obesity-Induced Adipose Insulin Resistance by Inhibiting the Class II MHC in Adipocytes.肾上腺髓质素2通过抑制脂肪细胞中的II类主要组织相容性复合体来改善早期肥胖诱导的脂肪胰岛素抵抗。
Diabetes. 2016 Aug;65(8):2342-55. doi: 10.2337/db15-1626. Epub 2016 May 3.
8
Prognostic Value of Plasma Intermedin Level in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome.血浆中间素水平在非ST段抬高型急性冠状动脉综合征患者中的预后价值
Medicine (Baltimore). 2016 Apr;95(16):e3422. doi: 10.1097/MD.0000000000003422.
9
Intermedin Restores Hyperhomocysteinemia-induced Macrophage Polarization and Improves Insulin Resistance in Mice.肾上腺髓质素恢复高同型半胱氨酸血症诱导的巨噬细胞极化并改善小鼠胰岛素抵抗。
J Biol Chem. 2016 Jun 3;291(23):12336-45. doi: 10.1074/jbc.M115.702654. Epub 2016 Apr 14.
10
Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.高胆固醇血症通过诱导氧化应激上调大鼠主动脉中肾上腺髓质素及其受体组分的表达。
Ann Clin Lab Sci. 2016 Winter;46(1):5-17.

肾上腺髓质素 2/中介素：一种潜在的治疗心脏代谢疾病的药物候选物。

Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases.

机构信息

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.

出版信息

Br J Pharmacol. 2018 Apr;175(8):1230-1240. doi: 10.1111/bph.13814. Epub 2017 May 16.

DOI:10.1111/bph.13814
PMID:28407200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5867024/
Abstract

UNLABELLED

Adrenomedullin (ADM) 2/intermedin (IMD) is a short peptide that belongs to the CGRP superfamily. Although it shares receptors with CGRP, ADM and amylin, ADM2 has significant and unique functions in the cardiovascular system. In the past decade, the cardiovascular effect of ADM2 has been carefully analysed. In this review, progress in understanding the effects of ADM2 on the cardiovascular system and its protective role in cardiometabolic diseases are summarized.

LINKED ARTICLES

This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.

摘要

未加标签

肾上腺髓质素（ADM）2/中介素（IMD）是一种短肽，属于 CGRP 超家族。虽然它与 CGRP、ADM 和胰淀素共享受体，但 ADM2 在心血管系统中具有重要且独特的功能。在过去的十年中，ADM2 的心血管作用已被仔细分析。在这篇综述中，总结了对 ADM2 对心血管系统的影响及其在心脏代谢疾病中的保护作用的理解进展。

相关文章

本文是心血管疾病小分子专题的一部分。要查看本节中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.